单细胞时代的破骨细胞生物学。

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Materials & Interfaces Pub Date : 2022-09-02 DOI:10.1186/s41232-022-00213-x
Masayuki Tsukasaki, Hiroshi Takayanagi
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引用次数: 7

摘要

破骨细胞是唯一能够吸收骨的细胞,在骨质疏松、关节炎、牙周炎和骨转移等病理条件下的骨稳态和骨损伤中起着核心作用。最近使用单细胞技术的研究以前所未有的分辨率揭示了破骨细胞发生的调节机制,并揭示了破骨细胞谱系细胞的起源、功能和命运存在异质性的可能性。在这里,我们讨论了破骨细胞生物学的最新进展和新概念。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Osteoclast biology in the single-cell era.

Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as well as bone damage under pathological conditions such as osteoporosis, arthritis, periodontitis, and bone metastasis. Recent studies using single-cell technologies have uncovered the regulatory mechanisms underlying osteoclastogenesis at unprecedented resolution and shed light on the possibility that there is heterogeneity in the origin, function, and fate of osteoclast-lineage cells. Here, we discuss the current advances and emerging concepts in osteoclast biology.

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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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