社区妇女外周血HIF3A DNA甲基化程度与肥胖积累之间的关系:Yakumo研究

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Endocrine Research Pub Date : 2022-08-01 Epub Date: 2022-09-14 DOI:10.1080/07435800.2022.2121967

Genki Mizuno, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Yoshitaka Ando, Ryosuke Fujii, Yoshiki Tsuboi, Atsushi Teshigawara, Itsuki Kageyama, Keisuke Osakabe, Keiko Sugimoto, Hiroaki Ishikawa, Naohiro Ichino, Yoshiji Ohta, Koji Ohashi, Shuji Hashimoto, Koji Suzuki

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引用次数: 0

摘要

简介:HIF3A内含子1 CpG位点的DNA甲基化与体重指数(BMI)相关。这项横断面研究调查了日本人群中HIF3A DNA甲基化与BMI或肥胖参数之间的相关性。方法:采用焦磷酸测序法定量检测HIF3A的DNA甲基化。结果:HIF3A DNA甲基化仅在女性中存在差异;在排除吸烟者后，cg27146050的DNA甲基化水平与内脏脂肪组织厚度相关，并与BMI和体脂百分比相关。结论:日本女性外周血HIF3A CpG位点(cg27146050) DNA甲基化与VAT厚度相关。

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Association between the Extent of Peripheral Blood DNA Methylation of HIF3A and Accumulation of Adiposity in community-dwelling Women: The Yakumo Study.

Introduction: DNA methylation in the CpG sites of intron 1 of HIF3A is associated with body mass index (BMI). This cross-sectional study investigated correlations between DNA methylation of HIF3A and BMI or adiposity parameters in the Japanese population.

Method: DNA methylation of HIF3A was quantified via pyrosequencing.

Result: DNA methylation of HIF3A differed only in women; DNA methylation level at cg27146050 was associated with visceral adipose tissue thickness and correlated with BMI and percent (%) body fat after excluding smokers.

Conclusion: Peripheral blood DNA methylation at the CpG site (cg27146050) of HIF3A correlated with VAT thickness in Japanese women.

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.