斜颈是儿童中枢神经系统肿瘤的主要症状:一项系统综述

IF 3 3区 医学 Q2 ONCOLOGY Seminars in oncology Pub Date : 2022-10-01 DOI:10.1053/j.seminoncol.2022.09.003
Nadejda Baklizi, Musthafa Raswoli, Michala Burges, Daniel C. Moreira, Ibrahim Qaddoumi
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引用次数: 1

摘要

评估斜颈作为小儿中枢神经系统肿瘤的主诉症状的频率及其对诊断前症状间隔(PSIs)和患者预后的影响。我们对报道患有各种中枢神经系统肿瘤的儿童斜颈的研究进行了系统回顾。我们在PubMed检索1972年1月至2021年3月发表的英文研究。如果符合以下标准,病例报告将被纳入分析(1)斜颈是继发于中枢神经系统肿瘤的表现症状(2)儿童及18岁,(3)接受影像学干预,(4)提供结局数据。在1365篇相关文章中,45篇符合纳入标准,代表95名患者。两名独立调查人员提取了数据,第三名调查人员对差异进行了仲裁。我们发现38.9%的中枢神经系统肿瘤以斜颈为唯一的表现。低级别肿瘤的PSI长度为0 - 4年(中位5个月),患者年龄与PSI长度呈负相关。在低级别肿瘤患者中,23.8%的患者接受了物理治疗,而在高级别肿瘤患者中,这一比例为0%。接受康复治疗的患者的PSI长度也有所增加,高级别和低级别肿瘤患者分别有39.3%和7.1%死于疾病。以低度肿瘤和斜颈为主要表现症状的患者更有可能延长PSI。因此,小儿获得性斜颈的鉴别诊断应考虑中枢神经系统肿瘤。
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Torticollis as a presenting symptom of pediatric CNS tumors: A systematic review

To assess the frequency of torticollis as a presenting symptom of pediatric CNS tumors and its impact on pre-diagnostic symptom intervals (PSIs) and patient outcomes. We performed a systematic review of studies reporting torticollis in children with various CNS tumors. We searched PubMed for studies published from January 1972 to March 2021 in English. Case reports were included in the analysis if the following criteria were met (1) torticollis was the presenting symptom secondary to a CNS tumor (2) children <18 years of age, (3) underwent imaging intervention and (4) outcome data provided. Of 1,365 relevant articles, 45 were eligible for analysis according to our inclusion criteria representing 95 patients. Two independent investigators extracted the data, and a third investigator arbitrated discrepancies. We found that 38.9% of CNS tumors exhibited torticollis as the only presenting symptom. PSI lengths ranged from 0 to 4 years (median, 5 months) for low-grade tumors, and patient age and PSI length were inversely associated. Of patients with low-grade tumors, 23.8% received physiotherapy, in contrast with 0% of patients with high-grade tumors. PSI length also increased for patients who received rehabilitation, and 39.3% and 7.1% of patients with high-grade and low-grade tumors, respectively, died of their disease. Patients with low-grade tumors and torticollis as a primary presenting symptom were more likely to have a prolonged PSI. Therefore, CNS tumors should be considered in the differential diagnosis of acquired torticollis in children.

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来源期刊
Seminars in oncology
Seminars in oncology 医学-肿瘤学
CiteScore
6.60
自引率
0.00%
发文量
58
审稿时长
104 days
期刊介绍: Seminars in Oncology brings you current, authoritative, and practical reviews of developments in the etiology, diagnosis and management of cancer. Each issue examines topics of clinical importance, with an emphasis on providing both the basic knowledge needed to better understand a topic as well as evidence-based opinions from leaders in the field. Seminars in Oncology also seeks to be a venue for sharing a diversity of opinions including those that might be considered "outside the box". We welcome a healthy and respectful exchange of opinions and urge you to approach us with your insights as well as suggestions of topics that you deem worthy of coverage. By helping the reader understand the basic biology and the therapy of cancer as they learn the nuances from experts, all in a journal that encourages the exchange of ideas we aim to help move the treatment of cancer forward.
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