酮替芬预防哮喘:对1791例全科治疗病例的分析

Le Poumon et le coeur Pub Date : 1982-03-01
B Lebeau, B Gence, M Bourdain, Y Loria
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引用次数: 0

摘要

酮替芬是一种新的哮喘预防治疗方法,其主要优点是口服给药。分析1 791例变应性发作性哮喘患者的治疗结果,每日剂量2 mg,至少持续3个月。酮替芬被发现对哮喘发作有效(30%的病例不再发作,35%的病例发作频率至少减少一半),而且相关的抗哮喘药物可以被抑制。治疗两周后出现积极效果,观察期间(3个月)改善程度增加。耐受性良好,主要副作用是嗜睡(13%的病例),在治疗早期发生,但在这些患者中有三分之一以上是可逆的。
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[Preventive treatment of asthma with ketotifen : an analysis of 1 791 cases treated in general practice].

Ketotifene is a new preventive treatment for asthma possessing the main advantage of being administered orally. Results were analyzed after treatment of 1 791 patients with allergic paroxysmal asthma, at a daily dose of 2 mg for a minimum duration of 3 months. Ketotifene was found to be effective both against asthma attacks (no further episodes in 30% of cases, and reduction in their frequency by at least a half in 35%), and by the fact that associated anti-asthma medication could be suppressed. Positive effects were noted after two weeks of treatment, with improvement increasing during the observation period (3 months). Tolerance was good, the principal side effect being somnolence (13% of cases), which occurred early in treatment but was reversible in more than one-third of these patients.

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