口腔黏膜原位黑色素瘤:1例报告及文献系统回顾。

IF 0.7 Q4 OTORHINOLARYNGOLOGY Turkish Archives of Otorhinolaryngology Pub Date : 2022-09-01 Epub Date: 2022-11-15 DOI:10.4274/tao.2022.2022-7-5
Polly Jasper, W Nicholas Jungbauer, Nicolas S Poupore, Shaun A Nguyen, Jim Howell, Brad W Neville, Terry A Day
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引用次数: 1

摘要

目的:头颈部的恶性黏膜黑色素瘤占所有黑色素瘤的很小一部分,特别是在口腔。这些病变与高局部复发率、远处转移率和极低的5年生存率相关;然而,口腔黏膜原位黑色素瘤的临床结果尚不清楚。因此,我们提出一个病例报告粘膜黑色素瘤原位和系统的文献回顾,以阐明这种罕见但重要的疾病。方法:根据系统评价和荟萃分析指南的首选报告项目检索PubMed、Scopus和CINAHL。只有当研究描述了口腔原位黑色素瘤,并记录了与治疗有关的具体数据,包括治疗方式、病变大小或结果时,才会考虑纳入研究。结果:28例文献报道病例符合纳入标准,1例来自本院。男性占大多数(64.3%),平均发病年龄为57.4岁。硬腭是最常见的部位,大多数病例采用手术切除治疗。8名患者在至少6个月的随访后没有任何疾病迹象,1名报告扩散到颈部淋巴结,只有1名报告进展并伴有远处转移。结论:口腔黏膜原位黑色素瘤是一种罕见的肿瘤,治疗方法多为手术切除。复发率高,需要长期随访。进一步的研究可能有助于确定辅助治疗是否在减少复发中发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Mucosal Melanoma In Situ of the Oral Cavity: A Case Report and Systematic Review of the Literature.

Objective: Malignant mucosal melanomas of the head and neck comprise a very small portion of all melanomas, particularly in the oral cavity. These lesions are associated with high rates of local recurrence, distant metastasis, and a very poor 5-year survival rate; however, the clinical outcomes of mucosal melanoma in situ of the oral cavity are unclear. Therefore, we present a case report of mucosal melanoma in situ and a systematic review of the literature to shed light on this rare but important disease.

Methods: PubMed, Scopus, and CINAHL were searched per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were only considered for inclusion if they described oral cavity melanoma in situ and documented specific data pertaining to treatment including modality, lesion size, or outcomes.

Results: A total of 28 reported cases from the literature fulfilled the inclusion criteria, as well as one case from our own institution. Men comprised the majority (64.3%) of the cases, and the average age at presentation was 57.4 years. The hard palate was the most common location, and most cases were treated with surgical excision. Eight had no evidence of disease after a minimum of six months of follow-up, one reported spread to the cervical lymph nodes, and only one reported progression with distant metastasis.

Conclusion: Oral mucosal melanoma in situ is a rare entity and most commonly treated with surgical excision. High rates of recurrence necessitate long term follow-up. Further studies may be useful to determine whether adjuvant therapy may play a role in reducing recurrence.

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