Parsa Firoozi, Mohammad Amin Amiri, Negin Soghli, Nima Farshidfar, Neda Hakimiha, Reza Fekrazad
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引用次数: 1
摘要
背景:光生物调节疗法是指将组织暴露在光源(包括发光二极管或低强度激光)下,从而调节细胞功能。研究揭示了这种疗法的分子机制,表明根据所使用的光设置,这种疗法有可能引起刺激性和抑制性反应:本系统综述旨在评估光生物调制疗法对牙科干细胞的影响,并提供这方面的循证结论:本系统综述根据《系统综述与元分析首选报告项目》(Preferred Reporting Items for Systematic Reviews and Meta-Analysis,PRISMA)修订版指南进行报告。采用 PICO(S) 要素来确定纳入标准。检索了截至 2021 年 9 月的科学网、Scopus、Medline 以及灰色文献和谷歌学者,以检索相关论文:结果:光生物调节疗法对牙科干细胞的增殖、活力和分化具有良好的效果。结论:尽管光生物调制疗法对牙科干细胞的增殖、活力和分化有积极作用,但这一发现是基于对偏倚风险较低的相关文章的综述:结论:尽管光生物调制疗法对牙科干细胞有积极的益处,但目前的数据并未就增强细胞活力、增殖和分化的最佳物理参数得出明确结论。
The Role of Photobiomodulation on Dental-Derived Stem Cells in Regenerative Dentistry: A Comprehensive Systematic Review.
Background: Photobiomodulation therapy involves exposing tissues to light sources, including light-emitting diodes or low-level lasers, which results in cellular function modulation. The molecular mechanism of this treatment is revealed, demonstrating that depending on the light settings utilized, it has the potential to elicit both stimulatory and inhibitory reactions.
Objective: The current systematic review aimed to evaluate the impact of photobiomodulation therapy on dental stem cells and provide an evidence-based conclusion in this regard.
Methods: This systematic review was performed and reported based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) revised guidelines. PICO(S) components were employed to define the inclusion criteria. Web of Science, Scopus, Medline as well as grey literature, and google scholar were searched up to September 2021 to retrieve relevant papers.
Results: Photobiomodulation therapy showed promising effects on the proliferation, viability, and differentiation of dental stem cells. This finding was based on reviewing related articles with a low risk of bias.
Conclusion: Despite the positive benefits of photobiomodulation therapy on dental stem cells, the current data do not provide a definitive conclusion on the best physical parameters for enhancing cell viability, proliferation, and differentiation.
期刊介绍:
Current Stem Cell Research & Therapy publishes high quality frontier reviews, drug clinical trial studies and guest edited issues on all aspects of basic research on stem cells and their uses in clinical therapy. The journal is essential reading for all researchers and clinicians involved in stem cells research.