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引用次数: 0
摘要
高等生物基因组的大部分由转座元件（TE）拷贝组成，即基因寄生虫。宿主与寄生虫的关系是多方面的，因基因组区域（基因与基因间）、生命周期阶段、组织类型以及健康与病理状态而异。虽然功能基因组学在研究基因型与表型之间的关系时，涉及 TEs 的研究范围有限。本综述旨在重点介绍在了解 TE 起源的生化活动如何与宿主基因组的核心阶段相互作用方面取得的最新进展。这种相互作用还能调节免疫环境，这可能会对免疫发挥作用的疾病状态产生重要影响。因此，本综述旨在围绕确定宿主基因组和遗传寄生虫进化适应性以及它们为何可能具有相关性提出想法和行动要点。
Recent insights into crosstalk between genetic parasites and their host genome.
The bulk of higher order organismal genomes is comprised of transposable element (TE) copies, i.e. genetic parasites. The host-parasite relation is multi-faceted, varying across genomic region (genic versus intergenic), life-cycle stages, tissue-type and of course in health versus pathological state. The reach of functional genomics though, in investigating genotype-to-phenotype relations, has been limited when TEs are involved. The aim of this review is to highlight recent progress made in understanding how TE origin biochemical activity interacts with the central dogma stages of the host genome. Such interaction can also bring about modulation of the immune context and this could have important repercussions in disease state where immunity has a role to play. Thus, the review is to instigate ideas and action points around identifying evolutionary adaptations that the host genome and the genetic parasite have evolved and why they could be relevant.
期刊介绍：
Briefings in Functional Genomics publishes high quality peer reviewed articles that focus on the use, development or exploitation of genomic approaches, and their application to all areas of biological research. As well as exploring thematic areas where these techniques and protocols are being used, articles review the impact that these approaches have had, or are likely to have, on their field. Subjects covered by the Journal include but are not restricted to: the identification and functional characterisation of coding and non-coding features in genomes, microarray technologies, gene expression profiling, next generation sequencing, pharmacogenomics, phenomics, SNP technologies, transgenic systems, mutation screens and genotyping. Articles range in scope and depth from the introductory level to specific details of protocols and analyses, encompassing bacterial, fungal, plant, animal and human data.
The editorial board welcome the submission of review articles for publication. Essential criteria for the publication of papers is that they do not contain primary data, and that they are high quality, clearly written review articles which provide a balanced, highly informative and up to date perspective to researchers in the field of functional genomics.
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