{"title":"热原类固醇对动物的炎症作用。","authors":"R H PALMER","doi":"10.3181/00379727-119-30110","DOIUrl":null,"url":null,"abstract":"Summary Three steroid pyrogens known to produce fever and inflammation in man were examined for inflammatory activity in rabbits, guinea pigs, hamsters, rats and dogs. Etiocholanolone, 11-ketopregnanolone and lithocholic acid are all capable of eliciting intense inflammatory reactions in experimental animals, although considerable variation in individual and species sensitivity was observed. Lithocholic acid, like the neutral steroids, failed to produce fever in rabbits, rats, dogs, cats and monkeys, thus confirming the highly specific nature of this activity in humans.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"108-11"},"PeriodicalIF":0.0000,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30110","citationCount":"6","resultStr":"{\"title\":\"INFLAMMATORY EFFECTS OF PYROGENIC STEROIDS IN ANIMALS.\",\"authors\":\"R H PALMER\",\"doi\":\"10.3181/00379727-119-30110\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Summary Three steroid pyrogens known to produce fever and inflammation in man were examined for inflammatory activity in rabbits, guinea pigs, hamsters, rats and dogs. Etiocholanolone, 11-ketopregnanolone and lithocholic acid are all capable of eliciting intense inflammatory reactions in experimental animals, although considerable variation in individual and species sensitivity was observed. Lithocholic acid, like the neutral steroids, failed to produce fever in rabbits, rats, dogs, cats and monkeys, thus confirming the highly specific nature of this activity in humans.\",\"PeriodicalId\":20675,\"journal\":{\"name\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"108-11\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1965-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3181/00379727-119-30110\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3181/00379727-119-30110\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-119-30110","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
INFLAMMATORY EFFECTS OF PYROGENIC STEROIDS IN ANIMALS.
Summary Three steroid pyrogens known to produce fever and inflammation in man were examined for inflammatory activity in rabbits, guinea pigs, hamsters, rats and dogs. Etiocholanolone, 11-ketopregnanolone and lithocholic acid are all capable of eliciting intense inflammatory reactions in experimental animals, although considerable variation in individual and species sensitivity was observed. Lithocholic acid, like the neutral steroids, failed to produce fever in rabbits, rats, dogs, cats and monkeys, thus confirming the highly specific nature of this activity in humans.
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