过氧化物酶体增殖物激活受体γ:在代谢综合征中的作用

Rajbabu Pakala, Pramod Kuchulakanti, Seung-Woon Rha, Edouard Cheneau, Richard Baffour, Ron Waksman
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引用次数: 24

摘要

本文综述了PPARγ在人类脂肪形成、胰岛素致敏、脂质代谢、血压调节和血栓形成前状态等方面的功能,为这种核受体继续作为治疗人类代谢综合征药物的关键治疗靶点提供了理由。
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Peroxisome proliferator-activated receptor γ: Its role in metabolic syndrome

Here we review PPARγ function in relation to human adipogenesis, insulin sensitization, lipid metabolism, blood pressure regulation and prothrombotic state to perhaps provide justification for this nuclear receptor remaining a key therapeutic target for the continuing development of agents to treat human metabolic syndrome.

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