{"title":"PLA-PLA纳米纤维生物医学支架的3D打印研究","authors":"Ranvijay Kumar, Rupinder Singh","doi":"10.1007/s40009-023-01261-8","DOIUrl":null,"url":null,"abstract":"<div><p>Architected scaffolds are being used extensively in tissue engineering applications. Some studies have reported the architected structures of polylactic acid (PLA) nanofibers (NF), prepared by fused filament fabrication (FFF)-based 3D printing. But hitherto little has been reported on the mechanical properties of PLA-PLA (NF)-PLA-based scaffolds. In this study, the PLA(NF) were electrospun in the first stage, and an architected scaffold of PLA-PLA(NF) (with 1, 2, and 3 layers)-PLA was prepared in the second stage. Further, the fracture morphology of the architected scaffolds was investigated from the crash-loading viewpoint. The PLA-PLA(2NF)-PLA scaffold resulted in an improved modulus of toughness (MoT) (5.62%) as compared to PLA. However, a significant drop in the elastic modulus (E) was observed. The maximum surface roughness (Ra: 204.50 nm) was observed at the fracture region of the PLA-PLA(3NF)-PLA scaffold. The results have been supported by scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) analysis.</p></div>","PeriodicalId":717,"journal":{"name":"National Academy Science Letters","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"On 3D Printing of Architected PLA-PLA Nanofiber-Based Biomedical Scaffolds\",\"authors\":\"Ranvijay Kumar, Rupinder Singh\",\"doi\":\"10.1007/s40009-023-01261-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Architected scaffolds are being used extensively in tissue engineering applications. Some studies have reported the architected structures of polylactic acid (PLA) nanofibers (NF), prepared by fused filament fabrication (FFF)-based 3D printing. But hitherto little has been reported on the mechanical properties of PLA-PLA (NF)-PLA-based scaffolds. In this study, the PLA(NF) were electrospun in the first stage, and an architected scaffold of PLA-PLA(NF) (with 1, 2, and 3 layers)-PLA was prepared in the second stage. Further, the fracture morphology of the architected scaffolds was investigated from the crash-loading viewpoint. The PLA-PLA(2NF)-PLA scaffold resulted in an improved modulus of toughness (MoT) (5.62%) as compared to PLA. However, a significant drop in the elastic modulus (E) was observed. The maximum surface roughness (Ra: 204.50 nm) was observed at the fracture region of the PLA-PLA(3NF)-PLA scaffold. The results have been supported by scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) analysis.</p></div>\",\"PeriodicalId\":717,\"journal\":{\"name\":\"National Academy Science Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2023-05-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"National Academy Science Letters\",\"FirstCategoryId\":\"4\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40009-023-01261-8\",\"RegionNum\":4,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"National Academy Science Letters","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1007/s40009-023-01261-8","RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
On 3D Printing of Architected PLA-PLA Nanofiber-Based Biomedical Scaffolds
Architected scaffolds are being used extensively in tissue engineering applications. Some studies have reported the architected structures of polylactic acid (PLA) nanofibers (NF), prepared by fused filament fabrication (FFF)-based 3D printing. But hitherto little has been reported on the mechanical properties of PLA-PLA (NF)-PLA-based scaffolds. In this study, the PLA(NF) were electrospun in the first stage, and an architected scaffold of PLA-PLA(NF) (with 1, 2, and 3 layers)-PLA was prepared in the second stage. Further, the fracture morphology of the architected scaffolds was investigated from the crash-loading viewpoint. The PLA-PLA(2NF)-PLA scaffold resulted in an improved modulus of toughness (MoT) (5.62%) as compared to PLA. However, a significant drop in the elastic modulus (E) was observed. The maximum surface roughness (Ra: 204.50 nm) was observed at the fracture region of the PLA-PLA(3NF)-PLA scaffold. The results have been supported by scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) analysis.
期刊介绍：
The National Academy Science Letters is published by the National Academy of Sciences, India, since 1978. The publication of this unique journal was started with a view to give quick and wide publicity to the innovations in all fields of science
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