【环状RNA在糖尿病伤口愈合中的作用机制研究进展】。

Q3 Medicine Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns Pub Date : 2023-05-20 DOI:10.3760/cma.j.cn501225-20220727-00317

Y Y Nong, X H Lyu

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引用次数: 0

摘要

近年来，大量研究表明，非编码RNA在伤口愈合过程中发挥着重要作用。其中，对环状RNA（circRNA）作用机制的研究表明，circRNA与内皮祖细胞、角质形成细胞等与伤口愈合相关的细胞的增殖密切相关，并且circRNA也参与了慢性伤口愈合过程。本文在介绍circRNA相关概念的基础上，重点探讨了circRNA在糖尿病伤口愈合不同阶段的可能调控机制，并总结了circ核糖核酸在糖尿病外周血管动脉粥样硬化过程中的潜在作用，目的深入探讨circRNA在糖尿病创面愈合过程中的分子机制及其临床意义，为进一步研究提供参考。

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[Research advances on the mechanism of circular RNA in diabetic wound healing].

In recent years, a large number of studies have shown that non-coding RNAs play an important role in wound healing process. Among them, studies on the mechanism of circular RNA (circRNA) have shown that circRNA is closely related to the proliferation of cells related to wound healing, such as endothelial progenitor cells and keratinocytes, and circRNA is also involved in the chronic wound healing process. Based on the introduction of the related concept of circRNA, this paper focuses on the possible regulatory mechanism of circRNA in different stages of diabetic wound healing and summarizes the potential role of circRNA in the process of diabetic peripheral vascular atherosclerosis, aiming to explore the in-depth molecular mechanism and clinical significance of circRNA in diabetic wound healing process, and provide reference for further research.

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来源期刊

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns Medicine-Medicine (all)

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8511

期刊介绍： The Chinese Journal of Burns is the most authoritative one in academic circles of burn medicine in China. It adheres to the principle of combining theory with practice and integrating popularization with progress and reflects advancements in clinical and scientific research in the field of burn in China. The readers of the journal include burn and plastic clinicians, and researchers focusing on burn area. The burn refers to many correlative medicine including pathophysiology, pathology, immunology, microbiology, biochemistry, cell biology, molecular biology, and bioengineering, etc. Shock, infection, internal organ injury, electrolytes and acid-base, wound repair and reconstruction, rehabilitation, all of which are also the basic problems of surgery.