1-苄基-2-甲基苯并咪唑衍生物对家蚕生长的调控作用。

IF 1.5 4区 农林科学 Q2 ENTOMOLOGY Journal of Pesticide Science Pub Date : 2023-08-20 DOI:10.1584/jpestics.D23-010
Shuhei Henmi, Ayumu Sueyoshi, Hiroshi Ono, Toshimasa Yamazaki, Konatsu Inoue, Takahiro Shiotsuki
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引用次数: 0

摘要

合成了1-苄基-2-甲基苯并咪唑衍生物(BMBIs),以评价其对鳞翅目模式昆虫家蚕的生物活性。合成的BMBI表现出两种不同的生物活性:抑制发育和急性致死。从结构角度来看,活性随着1-苄基部分上取代的位置而变化;在2和/或4位上具有取代的BMBI与在3位上具有替代的BMBI相比具有相对高的活性。低剂量对发育的抑制作用更强,高剂量对急性致死作用更强。该活性也受到施用阶段的影响,即4龄的施用主要干扰幼虫的蜕皮或化蛹,而3龄的施用则导致更严重的死亡率。总之,这些结果表明BMBI具有多种作用模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Insect growth-regulating activity of 1-benzyl-2-methylbenzimidazole derivatives on silkworms.

Derivatives of 1-benzyl-2-methylbenzimidazoles (BMBIs) were synthesized to evaluate their biological activities against Bombyx mori, a lepidopteran model insect. Synthesized BMBIs exhibited two different biological activities: inhibition of development and acute lethality. From a structural perspective, the activity varied with the position of the substitutions on the 1-benzyl moiety; BMBIs with substitutions on the 2 and/or 4 positions had comparatively high activity in comparison with those with substitutions on the 3-position. There was more activity for the inhibition of development with low doses, and more for acute lethality with high doses. The activity was also affected by the applied stage, that is, application in the 4th instar mostly interfered the larval molting or pupation, whereas that in the 3rd instar caused more acute mortality. Taken together, these results suggest that BMBIs have multiple modes of action.

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来源期刊
Journal of Pesticide Science
Journal of Pesticide Science 农林科学-昆虫学
CiteScore
4.30
自引率
4.20%
发文量
28
审稿时长
18-36 weeks
期刊介绍: The Journal of Pesticide Science publishes the results of original research regarding the chemistry and biochemistry of pesticides including bio-based materials. It also covers their metabolism, toxicology, environmental fate and formulation.
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