脂质谱作为胸腹手术后器官功能障碍的预测标志物:一项横断面研究。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2023-09-01 DOI:10.30476/IJMS.2022.95364.2672
Sarvin Sanaie, Sanam Dolati, Majid Montazer, Sarina Ranjbari, Arezoo Fathalizadeh, Kamran Shadvar, Elnaz Faramarzi, Ata Mahmoodpoor
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引用次数: 0

摘要

背景:血浆总胆固醇被认为是一种负急性期反应物。在各种病理条件下,如创伤、败血症、烧伤、肝功能障碍以及手术后,血清胆固醇水平下降。本研究旨在探讨脂质谱在确定手术后器官功能障碍概率中的作用。方法:这项横断面研究包括2016年10月至2018年9月期间接受胸腹手术并入住伊朗大不里士伊玛目礼萨医院重症监护室的患者。在入院的前两天,采集血样,测量血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白蛋白胆固醇(LDL-C)、甘油三酯(TG)和白蛋白水平。研究了这些实验室标志物的变化与六种器官功能之间的关系,包括心血管、呼吸、肾脏、中枢神经系统、肝脏和血液学、在医院和重症监护室的住院时间、机械通气持续时间和血管升压药的使用。独立t检验用于比较连续变量。采用逻辑回归法评估不同变量与器官功能障碍和死亡率之间的相关性。结果:血清TC增加了患者的死亡率(OR=1.09,95%CI=1.06-11.11,P结论:TC可被认为是死亡率、器官功能障碍和临床结果的危险因素。另一方面,LDL、HDL和TG对患者的死亡率、器官功能不全和临床结果起到保护作用。
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Lipid Profile as a Predictive Marker for Organ Dysfunction after Thoracoabdominal Surgery: A Cross-sectional Study.

Background: Plasma total cholesterol is considered a negative acute phase reactant. In various pathological conditions, such as trauma, sepsis, burns, and liver dysfunction, as well as post-surgery, serum cholesterol level decreases. This study aimed to investigate the role of lipid profiles in determining the probability of organ dysfunction after surgery.

Methods: This cross-sectional study included patients who underwent thoracoabdominal surgery and were admitted to the intensive care unit of Imam Reza Hospital in Tabriz, Iran, between October 2016 and September 2018. During the first two days of admission, blood samples were taken, and serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and albumin were measured. The relation between the changes in these laboratory markers and six organ functions including cardiovascular, respiratory, renal, central nervous system, hepatic, and hematologic, length of stay in the hospital and intensive care unit, mechanical ventilation duration, and vasopressor use were investigated. The independent t test was used to compare continuous variables. The association between different variables and organ dysfunction and mortality was evaluated by using logistic regression.

Results: The serum TC increased the risk of mortality (OR=1.09, 95%CI=1.06-1.11, P<0.001), renal dysfunction (OR=1.09, 95%CI=1.06-1.12; P<0.001), liver dysfunction (OR=1.07, 95%CI=1.03-1.10; P<0.001), respiratory dysfunction (OR=1.08, 95%CI=1.05-1.13; P<0.001). Moreover, LDL, HDL, and TG were found to be inversely related to mortality, organ dysfunction, length of stay in the hospital and intensive care unit, mechanical ventilation duration, and vasopressor use.

Conclusion: TC could be considered a risk factor for mortality, organ dysfunction, and clinical outcomes. On the other hand, LDL, HDL, and TG played a protective role in the patients' mortality, organ dysfunction, and clinical outcomes.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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