受体酪氨酸激酶相分离在癌症中的新作用。

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-05-01 Epub Date: 2023-09-28 DOI:10.1016/j.tcb.2023.09.002
Chi-Chuan Lin, Kin Man Suen, Jessica Lidster, John E Ladbury
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引用次数: 0

摘要

受体酪氨酸激酶(RTK)介导的信号转导是细胞功能的基础,并驱动重要的细胞结果,当失调时,可导致恶性肿瘤生长和转移。来自质膜结合的RTKs的信号的启动受到控制下游效应蛋白募集和功能的多种调节机制的影响。RTK通过液-液相分离(LLPS)浓缩成具有下游效应蛋白的无膜细胞器的高倾向性为信号调节提供了进一步的基本机制。在此,我们强调了这一现象如何促进癌症信号传导,并考虑了LLPS对癌症患者预后的潜在影响。
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The emerging role of receptor tyrosine kinase phase separation in cancer.

Receptor tyrosine kinase (RTK)-mediated signal transduction is fundamental to cell function and drives important cellular outcomes which, when dysregulated, can lead to malignant tumour growth and metastasis. The initiation of signals from plasma membrane-bound RTKs is subjected to multiple regulatory mechanisms that control downstream effector protein recruitment and function. The high propensity of RTKs to condense via liquid-liquid phase separation (LLPS) into membraneless organelles with downstream effector proteins provides a further fundamental mechanism for signal regulation. Herein we highlight how this phenomenon contributes to cancer signalling and consider the potential impact of LLPS on outcomes for cancer patients.

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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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