哺乳动物细胞如何处理噬菌体指南。

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2023-09-29 DOI:10.1146/annurev-virology-111821-111322
Leo Kan, Jeremy J Barr
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引用次数: 0

摘要

噬菌体是难以定义的神秘实体。通常,它们是专门寄生在细菌宿主身上的病毒。然而,当我们考虑到它们在体内的普遍性,以及它们与哺乳动物宿主直接相互作用的巨大能力时,这个定义就变得有限了。虽然噬菌体肯定不会感染哺乳动物细胞,也不会在哺乳动物细胞内复制,但它们确实与真核细胞结构相互作用,并获得不受限制的进入途径。随着人们对人类病毒组的日益重视,加上我们在临床环境中对患者应用噬菌体的增加,噬菌体与哺乳动物相互作用的潜在影响逐渐得到认识。在这篇综述中,我们提供了噬菌体如何与哺乳动物细胞表面相互作用的详细机制概述,所述噬菌体被细胞内化的过程,以及噬菌体的细胞内处理和命运。然后,我们总结了该领域关于噬菌体-哺乳动物相互作用及其与健康和疾病状态的关系的现状。
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A Mammalian Cell's Guide on How to Process a Bacteriophage.

Bacteriophages are enigmatic entities that defy definition. Classically, they are specialist viruses that exclusively parasitize bacterial hosts. Yet this definition becomes limiting when we consider their ubiquity in the body coupled with their vast capacity to directly interact with the mammalian host. While phages certainly do not infect nor replicate within mammalian cells, they do interact with and gain unfettered access to the eukaryotic cell structure. With the growing appreciation for the human virome, coupled with our increased application of phages to patients within clinical settings, the potential impact of phage-mammalian interactions is progressively recognized. In this review, we provide a detailed mechanistic overview of how phages interact with the mammalian cell surface, the processes through which said phages are internalized by the cell, and the intracellular processing and fate of the phages. We then summarize the current state-of-the-field with respect to phage-mammalian interactions and their associations with health and disease states.

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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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