马来西亚队列中的HLA-B*57:01分型：HIV感染者阿巴卡韦超敏反应的意义。

IF 1.9 4区医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics Pub Date : 2023-09-01 Epub Date: 2023-09-28 DOI:10.2217/pgs-2023-0136

V Kalidasan, Iswarya Kunalan, Reena Rajasuriar, Vijay Kumar Subbiah, Kumitaa Theva Das

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引用次数: 0

摘要

背景：阿巴卡韦（ABC）与其他抗逆转录病毒药物联合用于治疗艾滋病毒感染者（PLWH）。然而，它与易感个体的致命超敏反应有关，并与HLA-B*57:01等位基因密切相关。材料与方法：采用序列特异性引物聚合酶链式反应对152例患者（50例PLWH和102例HIV-1阴性患者）进行HLA-B*57:01等位基因检测。结果：所有PLWH的HLA-B*57:01等位基因检测结果均为阴性，但两名HIV阴性患者被发现具有HLA-B*57等位基因，其中一人表达HLA-B*57:001等位基因。结论：鉴于该风险等位基因在人群中的低患病率，检测PLWH中HLA-B*57:01的存在可能不会为报告的人群提供显著的益处。

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HLA-B*57:01 typing in a Malaysian cohort: implications of abacavir hypersensitivity in people living with HIV.

Background: Abacavir (ABC) in combination with other antiretroviral drugs, is used to treat people living with HIV (PLWH). However, it is linked to a fatal hypersensitivity reaction in susceptible individuals, and is strongly associated with the HLA-B*57:01 allele. Materials & methods: A total of 152 patients, 50 PLWH and 102 HIV-1 negative patients, were assessed for the HLA-B*57:01 allele through a sequence-specific primer PCR. Results: All PLWH tested negative for the HLA-B*57:01 allele, but two HIV-negative patients were found to have HLA-B*57, with one of them expressing the HLA-B*57:01 allele. Conclusion: Given the low prevalence of this risk allele in the population, testing for the presence of HLA-B*57:01 in PLWH may not provide significant benefit for the reported population.

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来源期刊

Pharmacogenomics 医学-药学

CiteScore

3.40

自引率

9.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.