有机饮食干预对成年队列中有机磷代谢产物水平的影响。

Neus González, Carla Pàmies, Paula Martinez, Laura Martí, José L Domingo, Martí Nadal, Montse Marquès
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引用次数: 0

摘要

农药是一组有机化合物,用于控制农业中的杂草或虫害。饮食是人类接触这些化合物的主要途径,即使摄入浓度较低,这些化合物也会导致严重的健康问题。因此,食用有机食品是减少接触农药的适当策略。进行了一项前瞻性随机研究,以评估有机饮食干预对尿二烷基磷酸酯(DAP)水平的影响。还对204种农药进行了筛选,以确认有机食品中不存在这些化合物。分析结果显示,在参与者食用的一个或多个有机食品样本中,204种农药中只有20种(9.8%)的浓度超过了定量限。它大大低于其他分析传统食物的研究中发现的杀虫剂水平,证实了这种饮食适合有机饮食干预。尿液中的大多数DAP代谢产物普遍减少,这是显著的(p
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Effects of an organic diet intervention on the levels of organophosphorus metabolites in an adult cohort.

Pesticides are a group of organic compounds used to control weeds or insect infestations in agriculture. Diet is the major route of human exposure to these compounds, which can cause serious health problems, even when the intake occurs at low concentrations. Hence, the consumption of organic food is an appropriate strategy to minimize the exposure to pesticides. A prospective, randomized study was conducted to assess the impact of an organic dietary intervention on the levels of urinary dialkyl phosphates (DAP). A screening of 204 pesticides was also carried out in order to confirm the absence of these compounds in organic food. The analytical results showed that only 20 of the 204 pesticides (9.8 %) had concentrations above the limit of quantification in one or more samples of the organic food consumed by the participants. It is substantially lower than the levels of pesticides found in other studies analysing conventional food, confirming the diet as suitable for the organic dietary intervention. A general reduction of most DAP metabolites in urine was found, being significant (p < 0.05) the decrease of dimethyl phosphate (DMP) (0.49 µg/g creatinine in Day 1 vs. 0.062 µg/g creatinine in Day 6), dimethyl thiophosphate (DMTP) (0.49 µg/g creatinine in Day 1 vs. 0.093 µg/g creatinine in Day 6) and diethyl phosphate (DEP) (0.28 µg/g creatinine in Day 1 vs. 0.12 µg/g creatinine in Day 6). In addition, the molar score for the total dimethyl DAP (ΣMP) and total dialkyl phosphate (ΣDAP) also showed significant differences after changing a conventional diet by an organic diet, being reduced from 0.008 µmol/g to 0.002 µmol/g for ΣMP and from 0.012 µmol/g to 0.003 µmol/g for ΣDAP. To the best of our knowledge, this is the first study that evaluates both the impact of an organic diet in the exposure to DAP and the levels of 204 pesticides in the organic food provided to the participants. In summary, the consumption of organic products decreases the dietary intake of pesticides, thus reducing also the potential adverse effects on human health.

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