牛分枝杆菌毒力的探索：来自比较基因组学的线索和对未来的展望。

IF 2.7 2区农林科学 Q1 VETERINARY SCIENCES Irish Veterinary Journal Pub Date : 2023-09-28 DOI:10.1186/s13620-023-00257-6

Morgane Mitermite, Jose Maria Urtasun Elizari, Ruoyao Ma, Damien Farrell, Stephen V Gordon

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摘要

在这里，我们提供了2022年6月在爱尔兰戈尔韦举行的2022年牛分枝杆菌会议上关于牛结核杆菌的全体演讲摘要。我们专注于分析牛分枝杆菌和人类病原体结核分枝杆菌之间的基因差异，以此了解是什么使牛分枝杆菌成为动物病原体。在我们从牛分枝杆菌基因组序列的研究中了解到的内容之前，我们提供了关于牛分枝杆菌的简要历史背景以及与结核分枝杆菌的比较毒力实验。我们讨论了将牛分枝杆菌毒力的分子基础知识转化为改进牛结核病控制的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future.

Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.

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来源期刊

Irish Veterinary Journal 农林科学-兽医学

CiteScore

4.80

自引率

3.40%

发文量

审稿时长

>36 weeks

期刊介绍： Irish Veterinary Journal is an open access journal with a vision to make a substantial contribution to the dissemination of evidence-based knowledge that will promote optimal health and welfare of both domestic and wild species of animals. Irish Veterinary Journal has a clinical research focus with an emphasis on the effective management of health in both individual and populations of animals. Published studies will be relevant to both the international veterinary profession and veterinary scientists. Papers relating to veterinary education, veterinary ethics, veterinary public health, or relevant studies in the area of social science (participatory research) are also within the scope of Irish Veterinary Journal.