基质密度调节脂肪细胞表型。

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM Adipocyte Pub Date : 2023-12-01 Epub Date: 2023-10-10 DOI:10.1080/21623945.2023.2268261
Alexander Ky, Atticus J McCoy, Carmen G Flesher, Nicole E Friend, Jie Li, Kore Akinleye, Christopher Patsalis, Carey N Lumeng, Andrew J Putnam, Robert W O'Rourke
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引用次数: 0

摘要

细胞外基质的改变导致代谢性疾病中的脂肪组织功能障碍。我们在可调水凝胶培养系统中研究了基质密度在调节人类脂肪细胞表型中的作用。相对于3%和10%,脂质积累在5重量%的中等水凝胶密度下最大。脂肪细胞中脂肪生成、脂质和氧化代谢基因途径在5%的水凝胶中富集,而纤维化基因途径在3%的水凝胶中丰富。这些数据表明,中等密度基质促进了更多的脂肪生成,更少的纤维化脂肪细胞表型,以增加脂质和有氧代谢。这些观察结果有助于越来越多的文献描述基质密度在调节脂肪组织功能中的作用。
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Matrix density regulates adipocyte phenotype.

Alterations of the extracellular matrix contribute to adipose tissue dysfunction in metabolic disease. We studied the role of matrix density in regulating human adipocyte phenotype in a tunable hydrogel culture system. Lipid accumulation was maximal in intermediate hydrogel density of 5 weight %, relative to 3% and 10%. Adipogenesis and lipid and oxidative metabolic gene pathways were enriched in adipocytes in 5% relative to 3% hydrogels, while fibrotic gene pathways were enriched in 3% hydrogels. These data demonstrate that the intermediate density matrix promotes a more adipogenic, less fibrotic adipocyte phenotype geared towards increased lipid and aerobic metabolism. These observations contribute to a growing literature describing the role of matrix density in regulating adipose tissue function.

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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
期刊最新文献
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