Jordan Carroll, Heather McCann, Glenda M. Halliday, John B. Kwok, Carol Dobson-Stone, Claire E. Shepherd
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Poly-GA immunohistochemistry is a reliable tool for detecting C9orf72 hexanucleotide repeat expansions
Poly-GA immunohistochemistry (A) on formalin fixed paraffin embedded cerebellum sections shows a similar distribution to p62 antibody (B) and reliably identifies neuronal cytoplasmic inclusions and neurites in cases with known C9orf72 repeat expansion. This is useful in the research setting where genetic testing has not been performed in life or suitable tissue is not avilable post-mortem.
期刊介绍：
Brain Pathology is the journal of choice for biomedical scientists investigating diseases of the nervous system. The official journal of the International Society of Neuropathology, Brain Pathology is a peer-reviewed quarterly publication that includes original research, review articles and symposia focuses on the pathogenesis of neurological disease.
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