阻塞性睡眠呼吸暂停的基因基础更新——炒作还是希望？

IF 2.8 3区医学 Q2 RESPIRATORY SYSTEM Current Opinion in Pulmonary Medicine Pub Date : 2023-11-01 Epub Date: 2023-09-01 DOI:10.1097/MCP.0000000000001011

Renata L Riha

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引用次数: 0

摘要

综述目的：阻塞性睡眠呼吸暂停综合征（OSAS）是西方社会的一种慢性常见疾病，如果不加以治疗，可能会导致不良的心脏代谢影响，也是日间嗜睡过度的最常见原因之一。最近的发现：OSAS的表现是多样的，被认为在每个个体中包括不同比例的不同中间表型和内型。不幸的是，由于其异质性和该领域工作人员对该疾病的定义不断变化，试图揭示OSAS的遗传基础一直充满困难。摘要：这篇简短的综述简要介绍了过去三十年在呼吸睡眠医学这一研究不足、资金不足的领域取得的成就。OSAS的基因基础仍然难以捉摸。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Update on the genetic basis of obstructive sleep apnoea - hype or hope?

Purpose of review: The obstructive sleep apnoea syndrome (OSAS) is a chronic, common condition in western societies which can lead to adverse cardiometabolic effects if left untreated and is one of the commonest causes of excessive daytime somnolence.

Recent findings: The presentation of OSAS is diverse and is thought to comprise of different intermediate phenotypes and endotypes in varying proportions in each individual. Unfortunately, due to its heterogeneity and the changing definitions of the disorder by workers in the field, attempts at revealing the genetic basis of OSAS has been fraught with difficulty.

Summary: This brief review presents a short update on the achievements of the past three decades in this understudied and underfunded area of endeavour in respiratory sleep medicine. The genetic underpinnings of OSAS remain elusive.

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来源期刊

Current Opinion in Pulmonary Medicine 医学-呼吸系统

CiteScore

6.20

自引率

0.00%

发文量

109

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Pulmonary Medicine is a highly regarded journal offering insightful editorials and on-the-mark invited reviews, covering key subjects such as asthma; cystic fibrosis; infectious diseases; diseases of the pleura; and sleep and respiratory neurobiology. Published bimonthly, each issue of Current Opinion in Pulmonary Medicine introduces world renowned guest editors and internationally recognized academics within the pulmonary field, delivering a widespread selection of expert assessments on the latest developments from the most recent literature.

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