术前全身炎症标志物作为分化型甲状腺癌症预后因素:一项系统综述和荟萃分析。

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2023-12-01 Epub Date: 2023-10-13 DOI:10.1007/s11154-023-09845-x
Elena Russo, Mathilda Guizzardi, Luca Canali, Francesca Gaino, Andrea Costantino, Gherardo Mazziotti, Andrea Lania, Silvia Uccella, Luca Di Tommaso, Fabio Ferreli, Luca Malvezzi, Giuseppe Spriano, Giuseppe Mercante
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引用次数: 0

摘要

背景:炎症与肿瘤发展有关,循环炎症生物标志物已被认为是几种实体瘤复发的可能预测因素。然而,炎症标志物在分化型甲状腺癌(DTC)中的作用仍不确定。目的:本荟萃分析旨在评估中性粒细胞与淋巴细胞之比(NLR)、淋巴细胞与单核细胞之比(LMR)和血小板与淋巴细胞之比来评估DTC患者的预后价值。方法:研究DTC患者的生存率与术前循环炎症标志物之间的关系。主要结果是无病生存率(DFS)。95%置信区间的风险比(log HR)的累积对数通过使用随机效应模型的逆方差法计算。结果:共纳入7599名患者,平均年龄48.89岁(95%CI 44.16-53.63)。对于NLR,DFS的估计合并对数HR为0.07(95%CI-0.12-0.26;p = 0.43),LMR为-0.58(95%CI-1.21-0.05;p = 0.06)和0.01(95%CI 0-0.01;p = 0.21)。结论:我们的荟萃分析显示,DTC中NLR、PLR、LMR和DFS之间没有关联;然而,需要更多的前瞻性数据来更好地定义DTC的炎症状态和预后之间的关系。
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Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis.

Background: Inflammation has been associated with tumor development and circulating inflammatory biomarkers have been proposed as possible predictors of recurrence of several solid tumors. However, the role of inflammation markers in differentiated thyroid carcinoma (DTC) is still uncertain.

Objective: This meta-analysis aimed to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with DTC.

Methods: Studies investigating the association between survival and preoperative circulating inflammatory markers in DTC patients were included. The primary outcome was disease-free survival (DFS). Cumulative logarithms of the hazard ratio (log-HRs) with 95% CI were calculated through the inverse variance method using a random-effects model.

Results: A total of 7599 patients with a mean age of 48.89 (95% CI 44.16-53.63) were included. The estimated pooled log-HRs for DFS were 0.07 for NLR (95% CI -0.12-0.26; p = 0.43), -0.58 for LMR (95% CI -1.21-0.05; p = 0.06), and 0.01 (95% CI 0-0.01; p = 0.21) for PLR.

Conclusions: Our meta-analysis showed no association between NLR, PLR, LMR and DFS in DTC; however, more prospective data are needed to better define the association between inflammatory status and prognosis of DTC.

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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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