胚胎移植实验:过去、现在和未来。

Trends in developmental biology Pub Date : 2017-01-01
Grace E Solini, Chen Dong, Margaret Saha
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引用次数: 0

摘要

取一块组织并将其移植到一个新的位置的过程对生命科学来说至关重要。移植技术在提供从癌症、进化生物学到发育生物学等生物学各个方面的基本理解方面发挥了重要作用。移植首先被早期胚胎学家采用,在阐明胚胎发育的几乎每个方面,包括细胞规格、承诺、细胞命运决定、胚胎诱导和可塑性方面,移植发挥了特别关键的作用。这篇综述将详细介绍细胞移植实验在揭示基本的发育和细胞生物学过程中所起的重要作用,以及它们对当代发育生物学的宝贵贡献。最后,它将为这项技术与当前的分子和测序技术在未来的工作中发挥作用提供富有成效的方向。
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Embryonic transplantation experiments: Past, present, and future.

The process of taking a piece of tissue and transplanting it into a novel location has been of paramount importance for life sciences. The technique of transplantation has served an important role in providing a basic understanding of all facets of biology ranging from cancer and evolutionary biology to developmental biology. First employed by early embryologists, transplantation has played a particularly critical role in elucidating virtually every aspect of embryonic development including cell specification, commitment, cell fate determination, embryonic induction, and plasticity. This review will detail the essential role cell transplantation experiments have played in uncovering fundamental developmental and cell biological processes as well as their valuable contribution to contemporary developmental biology. Finally, it will suggest fruitful directions that this technique, in conjunction with current molecular and sequencing technologies, could play in future work.

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