{"title":"CRISPR-Cas在疾病诊断和治疗中的应用","authors":"Zhiying Wang, Yin Liu, Fuling Zhou, Yafen Wang, Xiang Zhou","doi":"10.1007/s11426-023-1765-0","DOIUrl":null,"url":null,"abstract":"<div><p>Clustered regularly interspaced short palindromic repeat (CRISPR) has been gaining much attention in the modern medical field and has been widely used for the diagnosis and treatment of diseases in recent years. In this review, we will introduce the application of CRISPR in disease diagnosis and treatment, including its use in detecting pathogens, gene mutations, and genetic diseases, as well as its application in gene therapy for single-gene diseases, cancer, viral infectious diseases, and cardiovascular diseases. Additionally, we will discuss the potential future directions and challenges of CRISPR in the diagnosis and treatment of diseases, and provide a thorough overview of the ways in which CRISPR is used for diagnosing and treating diseases.</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"66 10","pages":"2734 - 2742"},"PeriodicalIF":10.4000,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The application of CRISPR-Cas in disease diagnosis and treatment\",\"authors\":\"Zhiying Wang, Yin Liu, Fuling Zhou, Yafen Wang, Xiang Zhou\",\"doi\":\"10.1007/s11426-023-1765-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Clustered regularly interspaced short palindromic repeat (CRISPR) has been gaining much attention in the modern medical field and has been widely used for the diagnosis and treatment of diseases in recent years. In this review, we will introduce the application of CRISPR in disease diagnosis and treatment, including its use in detecting pathogens, gene mutations, and genetic diseases, as well as its application in gene therapy for single-gene diseases, cancer, viral infectious diseases, and cardiovascular diseases. Additionally, we will discuss the potential future directions and challenges of CRISPR in the diagnosis and treatment of diseases, and provide a thorough overview of the ways in which CRISPR is used for diagnosing and treating diseases.</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>\",\"PeriodicalId\":772,\"journal\":{\"name\":\"Science China Chemistry\",\"volume\":\"66 10\",\"pages\":\"2734 - 2742\"},\"PeriodicalIF\":10.4000,\"publicationDate\":\"2023-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science China Chemistry\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11426-023-1765-0\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Chemistry","FirstCategoryId":"1","ListUrlMain":"https://link.springer.com/article/10.1007/s11426-023-1765-0","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
The application of CRISPR-Cas in disease diagnosis and treatment
Clustered regularly interspaced short palindromic repeat (CRISPR) has been gaining much attention in the modern medical field and has been widely used for the diagnosis and treatment of diseases in recent years. In this review, we will introduce the application of CRISPR in disease diagnosis and treatment, including its use in detecting pathogens, gene mutations, and genetic diseases, as well as its application in gene therapy for single-gene diseases, cancer, viral infectious diseases, and cardiovascular diseases. Additionally, we will discuss the potential future directions and challenges of CRISPR in the diagnosis and treatment of diseases, and provide a thorough overview of the ways in which CRISPR is used for diagnosing and treating diseases.
期刊介绍：
Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field.
Categories of articles include:
Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry.
Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies.
Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.
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