Purposeful Review to Identify the Benefits, Mechanism of Action and Practical Considerations of Omega-3 Polyunsaturated Fatty Acid Supplementation for the Management of Diabetes Mellitus

: Despite advances in medical management diabetes mellitus (DM), it remains on the rise and it is the major cause of morbidity and mortality. Its etiology is multifactorial involving environmental, genetic and behavioral origins. It is closely linked to sedentary life and inappropriate food intake. Patients with DM should know about the uses of correct nutritional habits, which is the key in the regulation of blood glucose. Despite the promising experimental investigations, currently, the clinical evidence for the usage of omega-3 supplementation for the management of DM and its complications is both conflicting and limited. In this narrative review, I will summarize recent findings about dietary sources, the potential mechanisms, benefits, and practical considerations on omega-3 polyunsaturated fatty acid supplementation for the management of DM. The search of literature for this narrative review was done comprehensively by using appropriate search terms and different electronic databases.