{"title":"黄嘌呤氧化酶活性对伊拉克肾结石患者某些生物标志物的影响","authors":"Ali Rasool, Mawj Razzak Ahmed","doi":"10.4103/mj.mj_27_23","DOIUrl":null,"url":null,"abstract":"Objective: Kidney stones are crystalline concrete that often develops inside the kidneys. Urinary tract problems are getting worse and worse for human health. The risk of end-stage kidney failure has been associated with increase the level of a new biomarker ( like xanthine oxidase) to assess severity of kidney injury. Methods: The eighty patients, who attended the government clinics in Yarmouk Teaching Hospital, and the forty healthy people were used as a control group. Colorimetric assays were used to assess serum xanthine oxidase (XO) and other biochemical parameters. Using an enzyme-linked immunosorbent assay was determined. Results: The mean serum XO activity (8.8525 IU/L) was significantly greater than the corresponding values for the controls (6.5825 IU/L). Patients with kidney stones showed abnormal activity of uric acid levels in 78.33% of cases, while XO activity showed highly sensitive (70%) and high specificity (79%). XO has been found to be an excellent biomarker for detecting damage of the kidney in people suffering from kidney stones.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of activity of xanthine oxidase on some biomarkers in patients with kidney stones in Iraqi Patients\",\"authors\":\"Ali Rasool, Mawj Razzak Ahmed\",\"doi\":\"10.4103/mj.mj_27_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: Kidney stones are crystalline concrete that often develops inside the kidneys. Urinary tract problems are getting worse and worse for human health. The risk of end-stage kidney failure has been associated with increase the level of a new biomarker ( like xanthine oxidase) to assess severity of kidney injury. Methods: The eighty patients, who attended the government clinics in Yarmouk Teaching Hospital, and the forty healthy people were used as a control group. Colorimetric assays were used to assess serum xanthine oxidase (XO) and other biochemical parameters. Using an enzyme-linked immunosorbent assay was determined. Results: The mean serum XO activity (8.8525 IU/L) was significantly greater than the corresponding values for the controls (6.5825 IU/L). Patients with kidney stones showed abnormal activity of uric acid levels in 78.33% of cases, while XO activity showed highly sensitive (70%) and high specificity (79%). XO has been found to be an excellent biomarker for detecting damage of the kidney in people suffering from kidney stones.\",\"PeriodicalId\":33069,\"journal\":{\"name\":\"mjl@ lmstnSry@ lTby@\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"mjl@ lmstnSry@ lTby@\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/mj.mj_27_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"mjl@ lmstnSry@ lTby@","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/mj.mj_27_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Impact of activity of xanthine oxidase on some biomarkers in patients with kidney stones in Iraqi Patients
Objective: Kidney stones are crystalline concrete that often develops inside the kidneys. Urinary tract problems are getting worse and worse for human health. The risk of end-stage kidney failure has been associated with increase the level of a new biomarker ( like xanthine oxidase) to assess severity of kidney injury. Methods: The eighty patients, who attended the government clinics in Yarmouk Teaching Hospital, and the forty healthy people were used as a control group. Colorimetric assays were used to assess serum xanthine oxidase (XO) and other biochemical parameters. Using an enzyme-linked immunosorbent assay was determined. Results: The mean serum XO activity (8.8525 IU/L) was significantly greater than the corresponding values for the controls (6.5825 IU/L). Patients with kidney stones showed abnormal activity of uric acid levels in 78.33% of cases, while XO activity showed highly sensitive (70%) and high specificity (79%). XO has been found to be an excellent biomarker for detecting damage of the kidney in people suffering from kidney stones.
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