脂质体给药系统作为治疗神经退行性疾病的新兴技术

A. Jadhav, Bharat T Agiwale, Chetan R Sonawane, S. Ahirrao, Smita Prakash Kakad, Sanjay J. Kshirsagar, Mrudula H. Bele
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引用次数: 0

摘要

在过去的十年里,由于世界人口的快速增长,神经退行性疾病(ND)的发病已经非常普遍。有许多神经退行性疾病,如阿尔茨海默病、帕金森病、脊髓性肌萎缩、利维体病等。阿尔茨海默病和帕金森病最常见。神经退行性疾病是由于大脑和脊髓中神经元的退化而发生的。这两种疾病的诊断都有所增加,然而,由于药物穿越血脑屏障(BBB)的能力较低,成功的治疗仍然非常有限。将药物输送到大脑是一个巨大的挑战,因为只有小的脂溶性药物穿过血脑屏障,通过考虑这一假设,脂质体药物输送系统被认为是神经退行性疾病的有效治疗方法之一。脂质体被认为是一种理想的载体,因为它们具有灵活性、生物相容性,并且可以携带不同类型的治疗分子穿过血脑屏障。本文综述了脂质递送系统在神经退行性疾病治疗中的潜在应用,以及脂质体在阿尔茨海默病和帕金森病中的应用。
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Liposomal Drug Delivery System as An Emerging Technique for Treatment Of Neurodegenerative Diseases
In the last decade, the onset of neurodegenerative diseases (ND) has been strongly widespread due to the rapid increase in the world population. There are many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, spinal muscular atrophy, Levy body disease, etc. Alzheimer’s disease and Parkinson’s disease are most commonly found. Neurodegenerative diseases occur due to the degradation of neurons in the brain and the spinal cord. The diagnosis of both diseases has increased, however, the successful treatment is still very limited because of the lower ability of the drug to cross the blood-brain barrier (BBB). It is a big challenge to deliver the drug to the brain, because only small and lipid-soluble agents cross the BBB, by considering this assumption, the liposomal drug delivery system is considered one of the effective treatments in neurodegenerative diseases. Liposomes are considered to be an ideal carrier as they are flexible, biocompatible, and can carry different types of therapeutic molecules across the BBB. This review focus on the potential use of lipid delivery system in the treatment of neurodegenerative diseases and the application of liposomes in Alzheimer's disease and Parkinson’s disease.
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来源期刊
Current Nanomedicine
Current Nanomedicine Medicine-Medicine (miscellaneous)
CiteScore
2.00
自引率
0.00%
发文量
15
期刊最新文献
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