Intensification of the extraction process of flavonoids and hydroxycinnamic acids from Tanacetum vulgare L. flowers

Background and Purpose: It has been shown that taking into account the polyvalence of action, tansy (Tanacetum vulgare L.) is a promising raw material for obtaining substances based on it as active pharmaceutical ingredients for the development of new potential herbal medicinal products. Materials and Methods: Ultrasound-assisted extraction (UAE) has been considered as one of the promising methods to optimize the technology of extracting biologically active substances (BAS) from T. vulgare flowers. Results: The advantages of the method, the mechanism of ultrasound action on plant cells, and the main factors affecting this process are indicated. Conclusion: The optimal technological parameters that allow the extraction of flavonoids calculated with reference to luteolin and hydroxycinnamic acids calculated with reference to chlorogenic acid in the maximum amount, namely, the raw material and extractant ratio, time, and the extraction frequency, have been determined. The high efficiency of UAE has been proven.