病例报告:空肠胃肠道间质瘤(GIST)

Alessandra Canelo, Alejandro Llanos-Salirrosas, E. López, J. Mantilla, L. Mejía, Sharon Polo
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引用次数: 0

摘要

胃肠道间质瘤(GIST)是一种间质肿瘤,占胃肠道肿瘤的不到3%,发病率为每十万居民1至2例。它更常起源于胃和小肠,以酪氨酸激酶生长因子受体CD117的表达为特征。因此,它的诊断需要免疫组织化学研究来排除其他间质肿瘤。然而,肠镜成像和活检分析可能提示术前诊断可能为GIST。本文报告一62岁妇女,经胶囊内窥镜观察,因肠中出血引起直肠出血及复发性贫血。肠镜检查显示空肠近端上皮下溃疡病变,活检显示解剖病理提示为胃肠道间质瘤。经免疫组化研究的活检样本证实了cKit/ cd117阳性GIST肿瘤的怀疑。手术切除尺寸为4.2x3 cm的肿瘤。术后患者病情稳定,临床随访至出院。临床发现、诊断和及时治疗有助于提高并发症的生存率。
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Case report: Gastrointestinal stromaal tumor (GIST) in the jejunum
Gastrointestinalstromaltumors(GIST)aremesenchymalneoplasmsthatrepresentlessthan3%of gastrointestinal neoplasms, with an incidence of 1 to 2 cases per hundred thousand inhabitants. It originates more frequently in the stomach and small intestine and is characterized by the expression of the tyrosine kinase growth factor receptor, CD117. Therefore, its diagnosis requires an immunohischemical study to rule it out from other mesenchymal tumors. However, enteroscopic imaging and analysis of the biopsy may suggest a preoperative diagnosis of probable GIST. The case of a 62-year-old woman with rectorrhagia and recurrent anemia caused by mid-intestinal bleeding observed by capsule endoscopy is reported. Enteroscopy revealed a subepithelial ulcerated lesion in the proximal jejunum, and a biopsy was taken, the anatomopathological study of which suggested a gastrointestinal stromal tumor. The biopsy sample subjected to immunohistochemical studies conrms the suspicion of a cKit/CD117-positive GIST tumor. Surgical resection of the tumor with dimensions 4.2x3 cm is performed. After surgery, the patient was stable and under clinical follow-up until she was discharged. Clinical ndings, diagnosis and timely treatment contribute to increasing survival from complications.
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12 weeks
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