DNA编码文库及其在RNA中的应用

IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Israel Journal of Chemistry Pub Date : 2023-07-10 DOI:10.1002/ijch.202300073
Xueyi Yang, Dr. Jessica L. Childs-Disney, Prof. M. Paegel, Prof. Matthew D. Disney
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引用次数: 1

摘要

结构RNA在调节生物过程中的功能作用,以及RNA作为有效治疗靶点的潜力,直到最近才得到重视。识别有效RNA配体的稳健和高通量方法对化学探针和治疗方法的发展至关重要。dna编码文库(DNA-encoded libraries, DEL)技术已经成为发现蛋白质配体的有力工具,它能够生成大型的、定制的、新颖的化学空间,为发现RNA配体设计的规则提供了前所未有的机会。本文综述了DEL选择的基本原理、DEL在RNA靶点上的应用进展以及DEL靶向RNA的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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DNA-Encoded Libraries and Their Application to RNA

The functional roles of structured RNAs in the regulation of biological processes, and hence RNA's potential as an effective therapeutic target, have only recently been appreciated. Robust and high-throughput methods that identify potent RNA ligands are critical to the development of chemical probes and therapeutics. DNA-encoded libraries (DEL) technology has emerged as a powerful tool for protein ligand discovery, and its ability to generate large, custom-tailored, and novel chemical space offers unprecedented opportunities to discover the rules of RNA ligand design. In this review, we discuss the basic principles of DEL selection, current progress on the application of DEL to RNA targets, and the outlook of targeting RNA by DEL.

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来源期刊
Israel Journal of Chemistry
Israel Journal of Chemistry 化学-化学综合
CiteScore
6.20
自引率
0.00%
发文量
62
审稿时长
6-12 weeks
期刊介绍: The fledgling State of Israel began to publish its scientific activity in 1951 under the general heading of Bulletin of the Research Council of Israel, which quickly split into sections to accommodate various fields in the growing academic community. In 1963, the Bulletin ceased publication and independent journals were born, with Section A becoming the new Israel Journal of Chemistry. The Israel Journal of Chemistry is the official journal of the Israel Chemical Society. Effective from Volume 50 (2010) it is published by Wiley-VCH. The Israel Journal of Chemistry is an international and peer-reviewed publication forum for Special Issues on timely research topics in all fields of chemistry: from biochemistry through organic and inorganic chemistry to polymer, physical and theoretical chemistry, including all interdisciplinary topics. Each topical issue is edited by one or several Guest Editors and primarily contains invited Review articles. Communications and Full Papers may be published occasionally, if they fit with the quality standards of the journal. The publication language is English and the journal is published twelve times a year.
期刊最新文献
Cover Picture: (Isr. J. Chem. 8-9/2024) Special Issue on RNA-Based Catalysts that Revolutionized the Discovery of Bioactive Peptides Hexagonal and Trigonal Quasiperiodic Tilings Breaking the Degeneracy of Sense Codons – How Far Can We Go? Cover Picture: (Isr. J. Chem. 6-7/2024)
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