{"title":"环状RNA及其在血液恶性肿瘤中的作用研究进展","authors":"A. Sun, Guangsen Zhang","doi":"10.3760/CMA.J.ISSN.1673-419X.2018.06.011","DOIUrl":null,"url":null,"abstract":"Circular RNA (circRNA) is a group of widely existed endogenous non-coding RNA. Its main structural feature is closed covalently cyclic loops and lack of the 5′-end, the 3′-end, and poly (A) tail, which resistant to degradation by RNA exonucleases and avoid debranching by adenylate debranching enzymes. Therefore, circRNA is stable in structure and function. Recent researches have revealed that circRNA mainly participates in transcriptional and posttranscriptional regulation, especially acts as microRNA (miRNA) sponge to regulate target gene expression as competitive endogenous RNA (ceRNA). circRNA is directly or indirectly involved in development of hematopoiesis in marrow and hematological malignancies, and is expected as a new diagnostic biomarker or molecular therapeutic target for hematological malignancies. In order to investigate relationships between circRNA and malignant transformation, therapeutic efficacy and prognosis of hematologic malignancies, this review summarizes the classification, characteristics, biological functions of circRNA and its role in hematopoiesis and hematologic malignancies. \n \n \nKey words: \nRNA, untranslated; microRNAs; Hematopoiesis; Hematologic neoplasms; Biological markers; circRNA","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"41 1","pages":"520-524"},"PeriodicalIF":0.0000,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Research progress of circular RNA and its roles in hematological malignancies\",\"authors\":\"A. Sun, Guangsen Zhang\",\"doi\":\"10.3760/CMA.J.ISSN.1673-419X.2018.06.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Circular RNA (circRNA) is a group of widely existed endogenous non-coding RNA. Its main structural feature is closed covalently cyclic loops and lack of the 5′-end, the 3′-end, and poly (A) tail, which resistant to degradation by RNA exonucleases and avoid debranching by adenylate debranching enzymes. Therefore, circRNA is stable in structure and function. Recent researches have revealed that circRNA mainly participates in transcriptional and posttranscriptional regulation, especially acts as microRNA (miRNA) sponge to regulate target gene expression as competitive endogenous RNA (ceRNA). circRNA is directly or indirectly involved in development of hematopoiesis in marrow and hematological malignancies, and is expected as a new diagnostic biomarker or molecular therapeutic target for hematological malignancies. In order to investigate relationships between circRNA and malignant transformation, therapeutic efficacy and prognosis of hematologic malignancies, this review summarizes the classification, characteristics, biological functions of circRNA and its role in hematopoiesis and hematologic malignancies. \\n \\n \\nKey words: \\nRNA, untranslated; microRNAs; Hematopoiesis; Hematologic neoplasms; Biological markers; circRNA\",\"PeriodicalId\":13774,\"journal\":{\"name\":\"国际输血及血液学杂志\",\"volume\":\"41 1\",\"pages\":\"520-524\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际输血及血液学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2018.06.011\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际输血及血液学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-419X.2018.06.011","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Research progress of circular RNA and its roles in hematological malignancies
Circular RNA (circRNA) is a group of widely existed endogenous non-coding RNA. Its main structural feature is closed covalently cyclic loops and lack of the 5′-end, the 3′-end, and poly (A) tail, which resistant to degradation by RNA exonucleases and avoid debranching by adenylate debranching enzymes. Therefore, circRNA is stable in structure and function. Recent researches have revealed that circRNA mainly participates in transcriptional and posttranscriptional regulation, especially acts as microRNA (miRNA) sponge to regulate target gene expression as competitive endogenous RNA (ceRNA). circRNA is directly or indirectly involved in development of hematopoiesis in marrow and hematological malignancies, and is expected as a new diagnostic biomarker or molecular therapeutic target for hematological malignancies. In order to investigate relationships between circRNA and malignant transformation, therapeutic efficacy and prognosis of hematologic malignancies, this review summarizes the classification, characteristics, biological functions of circRNA and its role in hematopoiesis and hematologic malignancies.
Key words:
RNA, untranslated; microRNAs; Hematopoiesis; Hematologic neoplasms; Biological markers; circRNA
期刊介绍：
The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.
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