抗sars - cov -2疫苗加强剂量引发的首例β-地中海贫血患者嗜血淋巴组织细胞增多症

IF 0.6 Q4 HEMATOLOGY Thalassemia Reports Pub Date : 2022-06-16 DOI:10.3390/thalassrep12020009
G. Calvaruso, M. Chiavetta, D. Renda, S. Raso, F. Dieli, V. L. Lentini, M. Gentile, A. Carroccio, A. Maggio
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引用次数: 1

摘要

背景:嗜血细胞性淋巴组织细胞增多症(HLH)是一种罕见且可能危及生命的系统性高炎症疾病,其病因有多种。临床病例:一名48岁的女性受输血依赖性β-地中海贫血影响,在我们的血液科住院,表现为间歇性发烧、血小板增多和全血细胞减少,在接种抗严重急性呼吸系统综合征冠状病毒2型信使核糖核酸疫苗加强剂几天后出现。住院期间进行的调查导致了HLH的诊断和类固醇治疗,其中开始静脉注射地塞米松并提供了益处。结论:HLH的严重性要求早期治疗,但疫苗接种后HLH患者的管理仍然具有挑战性,需要进一步研究。先前未描述地中海贫血患者的HLH病例。
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The First Case of Haemophagocytic Lymphohistiocytosis Triggered by the Booster Dose of Anti-SARS-CoV-2 Vaccine in a Patient with β-Thalassemia
Background: Haemophagocytic lymphohistiocytosis (HLH) is a rare and potentially life-threatening systemic hyperinflammatory disease, which can have several aetiologies. Clinical case: a 48-year-old woman affected by a transfusion-dependent β-thalassemia was hospitalized in our haematology unit presenting with intermittent fever, haepatosplenomegaly and pancytopenia, which developed a few days after the booster dose of anti-SARS-CoV-2 mRNA vaccine. The investigations performed during hospitalization led to a diagnosis of HLH and steroid therapy where IV dexamethasone was initiated and provided benefits. Conclusions: the severity of HLH mandates early treatment, but the management of patients with post-vaccine HLH is still challenging and requires further study. No cases of HLH in patients with thalassemia were previously described.
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来源期刊
Thalassemia Reports
Thalassemia Reports HEMATOLOGY-
自引率
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发文量
17
审稿时长
10 weeks
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