PmCBP-VP24复合物内分子相互作用的原位硅预测,以了解WSSV最初向虾体内的诱导作用

Q4 Agricultural and Biological Sciences Genetics of Aquatic Organisms Pub Date : 2021-05-13 DOI:10.4194/2459-1831-v5_2_05
Kanika Yadav, A. K. Verma, A. Pathak, Abhishek Awasthi
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引用次数: 3

摘要

白斑病是对虾最具毁灭性的疾病之一。对虾受体蛋白PmCBP(单尖对虾几丁质结合蛋白)与病毒包膜蛋白VP24之间的分子相互作用是白斑综合征病毒与对虾消化道结合的必要条件,这种锚定的失败导致感染无效。这项研究首次揭示了PmCBP-VP24复合物的分子相互作用,并为病毒侵入虾体内的初始步骤提供了重要线索。
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In Silico Prediction of Molecular Interaction Within PmCBP-VP24 Complex to Understand Initial Instigation of WSSV into Shrimps
White Spot Disease is one of the most devastating diseases of shrimps. Molecular interaction between shrimp receptor protein PmCBP (Chitin binding protein of Peneaus monodon) and viral envelop protein VP24 is obligatory for binding of the White Spot Syndrome Virus to the shrimp digestive tract, and failure of this anchoring leads to an ineffectual infection. This is a first study that throws light on the molecular interaction of PmCBP-VP24 complex and provides important clues for initial steps of ingression of the virus into shrimps.
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来源期刊
Genetics of Aquatic Organisms
Genetics of Aquatic Organisms Agricultural and Biological Sciences-Aquatic Science
CiteScore
0.90
自引率
0.00%
发文量
8
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