{"title":"Suramin.","authors":"M. Eisenberger, V. Sinibaldi, L. Reyno","doi":"10.32388/ogsz91","DOIUrl":null,"url":null,"abstract":"A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factorbeta (T GF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. T his agent also inhibits vascular endothelial growth factor (VEGF)and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04) Qeios · Definition, February 7, 2020","PeriodicalId":79323,"journal":{"name":"Cancer practice","volume":"3 3 1","pages":"187-9"},"PeriodicalIF":0.0000,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"20","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32388/ogsz91","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factorbeta (T GF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. T his agent also inhibits vascular endothelial growth factor (VEGF)and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04) Qeios · Definition, February 7, 2020
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