Pathogenetic relationship between kidney pathologies and the microcirculatory capillary layer in dogs under the influence of Babesia canis

With babesiosis in dogs, the capillary network is especially strongly affected due to the stimulation of the hemostasis system and the development of thrombus formation in the microvasculature. Acute renal failure and even death of animals are caused by shock phenomena and the syndrome of disseminated intravascular coagulation. Clinical, laboratory (hematological, biochemical, coagulometric, hemodynamic, enzyme immunoassay) methods of research were conducted. Dogs with babesiosis have fever, anemia, and hemoglobinuria, hematologically established anemia, systemic inflammation, thrombotic condition. Hemodynamic parameters determine the state of shock, which in dynamics becomes decompensated and irreversible. The appearance of poikilocytes in the blood of sick dogs indicates significant metabolic disorders in their body. The coagulogram reveals the syndrome of disseminated intravascular coagulation. Syndrome markers significantly changed with a trend to increase during nephropathy. In addition, uremia, hyperuricemia, hyperkalemia, hyponatremia, hyperphosphatemia, creatininemia were found in the sick dogs, which are reliable indicators and determine the development of an acute form of glomerulonephritis and progressive acute renal failure. According to the study of the general biochemical status in animals, hepatopathy in the form of acute hepatitis and pancreatitis, and general intoxication syndrome were established. In our findings: during acute spontaneous babesiosis, dogs developed nephropathy, which has two clinical stages: hemoglobinuria and oliguria/anuria. The pathogenetic basis for the development of glomerulonephritis and acute renal failure is the syndrome of disseminated intravascular coagulation in response to the influence of a pathogen, which causes shock, forming a vicious circle of shock. Under such conditions, renal failure increases and eventually leads to the death of the animal. The studied data will contribute to the expansion of the conceptual understanding of the pathogenesis of canine babesiosis and determine the leading role of complications in the development of kidney failure.