COVID - 19疫苗接种后伴有感觉共济失调、凝视诱发眼球震颤、精神状态改变和阳性病理反射的格林-巴勒综合征

Q4 Immunology and Microbiology Clinical and Experimental Neuroimmunology Pub Date : 2023-04-28 DOI:10.1111/cen3.12754

Nanami Saso, Shuta Toru, Keiichi Iwasaru, Hiroaki Yokote, Toshiki Uchihara

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摘要

据报道，接种2019冠状病毒疫苗后出现了各种神经系统疾病，其中一种是格林-巴罗综合征(GBS)。

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Post-COVID-19 vaccination Guillain–Barré syndrome with sensory ataxia, gaze-evoked nystagmus, mental-status change and positive pathological reflex

Background

Various neurological disorders have been reported after vaccination against coronavirus disease 2019, one of which is Guillain–Barré Syndrome (GBS).

Case Presentation

We report a case of a 73-year-old woman who developed GBS and extra-GBS manifestations 19 days after the second dose of BNT162b2 mRNA vaccine. She presented lower limb predominant muscle weakness and loss of tendon reflexes. Nerve conduction study showed acute motor and sensory axonal neuropathy. In addition, she developed notable deep sensory ataxia, and showed positive pathological reflex, gaze-evoked nystagmus and altered consciousness, which suggested brainstem involvement.