通过循环肿瘤DNA（ctDNA）进行泛癌筛查——最近的突破和慢性缺陷

IF 1.1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Journal of Laboratory Medicine Pub Date : 2022-07-18 DOI:10.1515/labmed-2022-0029

S. Holdenrieder, Vida Ungerer, Angela Oberhofer, A. Bronkhorst

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引用次数: 4

摘要

早期发现对肿瘤的最佳治疗和预后至关重要。泛癌症筛查的新方法包括通过下一代测序、突变和甲基化模式的分子谱以及片段化分析来全面表征血浆中循环肿瘤DNA (ctDNA)。这些技术有望在早期疾病阶段准确检测和定位多种癌症。然而，对真实筛查人群的研究必须显示其临床效用和实用性。

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Pan-cancer screening by circulating tumor DNA (ctDNA) – recent breakthroughs and chronic pitfalls

Abstract Early detection is crucial for optimal treatment and prognosis of cancer. New approaches for pan-cancer screening comprise the comprehensive characterization of circulating tumor DNA (ctDNA) in plasma by next generation sequencing and molecular profiling of mutations and methylation patterns, as well as fragmentation analysis. These promise the accurate detection and localization of multiple cancers in early disease stages. However, studies with real screening populations have to show their clinical utility and practicability.

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来源期刊

Journal of Laboratory Medicine Mathematics-Discrete Mathematics and Combinatorics

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Laboratory Medicine (JLM) is a bi-monthly published journal that reports on the latest developments in laboratory medicine. Particular focus is placed on the diagnostic aspects of the clinical laboratory, although technical, regulatory, and educational topics are equally covered. The Journal specializes in the publication of high-standard, competent and timely review articles on clinical, methodological and pathogenic aspects of modern laboratory diagnostics. These reviews are critically reviewed by expert reviewers and JLM’s Associate Editors who are specialists in the various subdisciplines of laboratory medicine. In addition, JLM publishes original research articles, case reports, point/counterpoint articles and letters to the editor, all of which are peer reviewed by at least two experts in the field.