Nomenclature for factors of the HLA system, update January, February and March 2022

The following sequences have been submitted to the Nomenclature Committee since theOctober, November andDecember 2021 nomenclature update (Marsh, 2022) and, following agreed policy, have been assigned official allele designations (Marsh et al., 2010). Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. An additional 295 alleles were recently published but have not been included in Table 3 due to space considerations (Turner et al., 2022). In addition, the sequence for the allele A*02:01:08 has been extended to become a new A*02 protein variant. The allele name A*02:01:08 has been abandoned and the sequence renamed A*02:1040. Furthermore, the sequence for the allele C*08:01:08 has been extended and shown to be a new silent variant of the C*08:22 protein group. The allele name C*08:01:08 has been abandoned and the sequence renamed C*08:22:02. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IPD-IMGT/HLADatabase using the sequence submission tool provided (Robinson et al., 2020). The IPD-IMGT/HLA Databasemay be accessed via www.ebi.ac.uk/ipd/imgt/hla.