靶向端粒和端粒酶治疗癌症的最新进展

Mohd Ashif Khan, Aakriti Garg, Imran A Khan, Nidhi
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引用次数: 0

摘要

端粒是保护染色体不受损伤的非编码DNA的重复序列。然而,随着细胞分裂,端粒的长度缩短,最终导致细胞衰老。端粒缩短通过端粒酶添加端粒序列来补偿,从而防止衰老,从而导致细胞异常生长并最终导致癌症。端粒酶可能对致癌作用没有直接影响,然而,端粒酶在维持端粒长度和肿瘤生长进展方面的作用是非常明显的。各种研究已经报道了端粒酶活性在肿瘤细胞中的意义。因此,靶向端粒酶可以成为癌症治疗的有效方法,而靶向端粒酶抑制的药物是未来临床应用于癌症治疗的可能候选药物。因此,在本文中,我们旨在综述各种针对癌症的端粒酶抑制剂,提出用于治疗癌症的端粒酶抑制剂的挑战,以及开发用于治疗癌症的端粒酶抑制剂。
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Current progress in targeting telomere and telomerase enzymes for the treatment of cancer
Telomere is the repetitive sequence of non-coding DNA that protects chromosomes from damage. However, with cell division, the length of the telomere gets shortened ultimately leading to cell senescence. Telomere shortening is compensated by the addition of telomeric sequence by telomerase enzyme and thus preventing senescence which may lead to abnormal cell growth and ultimately result in cancer. There might not be a direct effect of telomerase on carcinogenesis, however, the role of telomerase in maintaining the length of telomere and thus tumor growth progression is quite evident. Various studies have reported the significance of telomerase activity in tumor cells. Therefore, targeting the telomerase enzyme can be an effective approach for the management of cancer, and drugs targeting telomerase inhibition are possible therapeutic candidates to be used clinically for the treatment of cancer in the future. Thus, in the current paper, we aim to review various telomerase inhibitors against cancer, challenges in proposing telomerase inhibitors for the treatment of cancer, and future perspectives on developing telomerase inhibitors for the management of cancer.
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来源期刊
CiteScore
1.00
自引率
0.00%
发文量
50
期刊介绍: Current Cancer Therapy Reviews publishes frontier reviews on all the latest advances in clinical oncology, cancer therapy and pharmacology. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in cancer therapy.
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