Maria Müller, Julia Czarnecka, M. Brzeziński, Jakub Pruś, B. Kulak, Andrzej Hołubowski, M. Stasiak, B. Borowiec, Rut Bryl, Lisa Moncrieff, M. Dyszkiewicz-Konwińska
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Abstract Stem cells and their usage for a long time are thought to be the future and hope in modern medicine. In this review we summarize development in science and bioengineering in this field. Opening with a description of newly discovered and studied sources of stem cells acquisition we present scientific methods progress and their application like 3D printing or transdifferentiation mode of action and results of these techniques. Technologies of genome editing like transcription activator-like effector nuclease, zinc-finger nucleases, or CRISPR Cas9 are also presented. In disease treatment and tissue reconstruction stem cells have proved to be effective most times due to great proliferation and differentiation potentials in presented in this summary pre-clinical and clinical studies for diseases like peripheral nerve palsy, myocardial infarction and heart ischemic disease and corneal wound healing. Running title: Current stem cells technologies used in medicine
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