识别硫酸软骨素E单克隆抗体的性质

IF 0.2 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Glycoscience and Glycotechnology Pub Date : 2022-03-25 DOI:10.4052/tigg.2120.1j

Ippei Watanabe

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引用次数: 1

摘要

在体外研究中，硫酸软骨素E (chondroitin sulfate E, CSE)已被发现具有多种活性，表明其在生物体内的重要性。然而，CSE的体外功能尚未完全阐明。抗体已被用作评估糖链生物学作用的工具，但先前报道的抗体不仅与CSE反应，还与其他CS异构体反应。如果一种抗体具有高度特异性且仅能检测CSE，则可用于研究CSE的体外活性或作为检测以CSE异常表达或定位为标志的疾病的探针。本文概述了与CSE反应的抗体的性质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Properties of Monoclonal Antibodies Recognizing Chondroitin Sulfate E

In in vitro studies, chondroitin sulfate E (CSE) has been found to have various activities, suggesting its importance in the living body. However, the in vitro function of CSE has not been fully elucidated. Antibodies have been used as a tool for assessing the biological roles of sugar chains, but previously reported antibodies react not only with CSE but also with other CS isomers. If an antibody was highly speciﬁc and able to detect only CSE, it could be used to study the in vitro activities of CSE or as a probe for detecting diseases marked by abnormal expression or localization of CSE. This paper outlines the properties of antibodies that react with CSE.

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来源期刊

Trends in Glycoscience and Glycotechnology 生物-生化与分子生物学

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： TIGG is an international, bilingual journal covering glycoscience and glycotechnology and issued bimonthly since 1989. Since then editors are elected from academia and companies who agree to participate in a volunteer basis for the duration of four years. TIGG is an official journal of the Japanese Society of Carbohydrate Research. The journal covers the following categories. MINIREVIEWS describe recent progress in the fields of glycoscience and glycotechnology. Suggestions are always welcome in the form of a one-page synopsis (double spaced) addressed to the editor-in-chief. GLYCOTOPICS are short commentaries on the latest papers describing outstanding findings with background. GLYCODEBUTS introduce distinguished PhD theses or outstanding works of young scientists over the world in glycosciences and glycotechnologies. GLYCOFORUM is for our readers who wish to submit comments on scientific or social matters related to glycoscience and glycotechnology. LETTERS TO TIGG are for readers who wish to discuss contributions appearing in TIGG or matters related to FCCA.