三种抗眼镜蛇毒素致人死亡的临床前疗效测试

IF 3.6 Q2 TOXICOLOGY Toxicon: X Pub Date : 2022-06-01 DOI:10.1016/j.toxcx.2022.100124

Mitchel Otieno Okumu , James Mucunu Mbaria , Joseph Kangangi Gikunju , Paul Gichohi Mbuthia , Vincent Odongo Madadi , Francis Okumu Ochola , Kenneth Narotso Maloba , Joseph Gichuki Nderitu

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引用次数: 1

摘要

本研究旨在确定Inoserp、Vins生物制品和南非医学研究所(SAIMR)多价抗蛇毒血清在中和Naja ashei毒液致小鼠死亡中的功效。用有效剂量、中位有效比、效价、归一化效价、体积和中和100 mg NAV所需的抗蛇毒血清瓶数来表示抗蛇毒血清的中和效果。

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Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality

This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV).

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