{"title":"18F-FDG PET/CT和68Ga-FAPI-04 PET/CT在评估IgG4相关疾病类固醇治疗反应中的不同表现：一例报告","authors":"Guorong Jia, Dejian Bian, Chao Cheng, Meitang Wang, Changjing Zuo","doi":"10.3389/fnume.2022.1038797","DOIUrl":null,"url":null,"abstract":"<p><p>IgG4-related disease is a fibrous-inflammatory process belonging to immunomodulation disorders. We report a case of a 57-year-old man with the IgG4-related disease (RD). <sup>68</sup>Ga-FAPI-04 PET/CT showed more significant uptake in most lesions than in <sup>18</sup>F-FDG PET/CT except for the cervical and mediastinal lymph nodes. Besides, uptake in the submandibular glands were only detected in <sup>68</sup>Ga-FAPI-04 PET/CT. The biopsy result of the cervical lymph nodes confirmed the diagnosis of IgG4-related disease. After treatment, only slight FDG-avid cervical lymph nodes were observed in the <sup>18</sup>F-FDG PET/CT, while the raised uptake of <sup>68</sup>Ga-FAPI-04 could be observed in the pancreas and submandibular glands. <sup>68</sup>Ga-FAPI-04 PET-CT might have promising applications in evaluating IgG4-RD, whether in initial or follow-up imaging during steroid therapy.</p>","PeriodicalId":73095,"journal":{"name":"Frontiers in nuclear medicine (Lausanne, Switzerland)","volume":"2 1","pages":"1038797"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440933/pdf/","citationCount":"0","resultStr":"{\"title\":\"The different manifestations of <sup>18</sup>F-FDG PET/CT and <sup>68</sup>Ga-FAPI-04 PET/CT in evaluation of the steroid therapy response for IgG4-related disease: A case report.\",\"authors\":\"Guorong Jia, Dejian Bian, Chao Cheng, Meitang Wang, Changjing Zuo\",\"doi\":\"10.3389/fnume.2022.1038797\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>IgG4-related disease is a fibrous-inflammatory process belonging to immunomodulation disorders. We report a case of a 57-year-old man with the IgG4-related disease (RD). <sup>68</sup>Ga-FAPI-04 PET/CT showed more significant uptake in most lesions than in <sup>18</sup>F-FDG PET/CT except for the cervical and mediastinal lymph nodes. Besides, uptake in the submandibular glands were only detected in <sup>68</sup>Ga-FAPI-04 PET/CT. The biopsy result of the cervical lymph nodes confirmed the diagnosis of IgG4-related disease. After treatment, only slight FDG-avid cervical lymph nodes were observed in the <sup>18</sup>F-FDG PET/CT, while the raised uptake of <sup>68</sup>Ga-FAPI-04 could be observed in the pancreas and submandibular glands. <sup>68</sup>Ga-FAPI-04 PET-CT might have promising applications in evaluating IgG4-RD, whether in initial or follow-up imaging during steroid therapy.</p>\",\"PeriodicalId\":73095,\"journal\":{\"name\":\"Frontiers in nuclear medicine (Lausanne, Switzerland)\",\"volume\":\"2 1\",\"pages\":\"1038797\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440933/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in nuclear medicine (Lausanne, Switzerland)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/fnume.2022.1038797\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in nuclear medicine (Lausanne, Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fnume.2022.1038797","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
The different manifestations of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in evaluation of the steroid therapy response for IgG4-related disease: A case report.
IgG4-related disease is a fibrous-inflammatory process belonging to immunomodulation disorders. We report a case of a 57-year-old man with the IgG4-related disease (RD). 68Ga-FAPI-04 PET/CT showed more significant uptake in most lesions than in 18F-FDG PET/CT except for the cervical and mediastinal lymph nodes. Besides, uptake in the submandibular glands were only detected in 68Ga-FAPI-04 PET/CT. The biopsy result of the cervical lymph nodes confirmed the diagnosis of IgG4-related disease. After treatment, only slight FDG-avid cervical lymph nodes were observed in the 18F-FDG PET/CT, while the raised uptake of 68Ga-FAPI-04 could be observed in the pancreas and submandibular glands. 68Ga-FAPI-04 PET-CT might have promising applications in evaluating IgG4-RD, whether in initial or follow-up imaging during steroid therapy.
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