{"title":"螺旋聚二苯乙炔衍生物包被新型核-壳型手性固定相的高效液相色谱拆分手性醇对映体","authors":"R. Nishioka, Syuji Harada, Kazuhiro Umehara","doi":"10.15583/jpchrom.2019.019","DOIUrl":null,"url":null,"abstract":"Enantiomeric separation ability on high-performance liquid chromatography (HPLC) of novel chiral stationary phase (CSP) was evaluated. A chiral selector of the CSP investigated in this study (SUMICHIRALTM OA-SHELL P1) is one of helical poly(diphenylacetylene) derivatives which is coated on core-shell silica support. OA-SHELL P1 showed excellent chiral separation ability for a wide range of aromatic chiral alcohols and it was also effective for separation of some chiral carboxylic acids, ketones and lactones. It is considered to be a new option for enantiomeric separation of these chiral compounds. OA-SHELL P1 is used in normal phase mode with a mobile phase of simple composition and one of its features is easy method development. The analysis time is relatively short even with conventional HPLC system since a core-shell support with particle size of 2.6 μm is used.","PeriodicalId":91226,"journal":{"name":"Chromatography (Basel)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.15583/jpchrom.2019.019","citationCount":"2","resultStr":"{\"title\":\"Enantiomeric Separation of Chiral Alcohols Using Novel Core-Shell Type Chiral Stationary Phase Coated with Helical Poly(diphenylacetylene) Derivative by High-Performance Liquid Chromatography\",\"authors\":\"R. Nishioka, Syuji Harada, Kazuhiro Umehara\",\"doi\":\"10.15583/jpchrom.2019.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Enantiomeric separation ability on high-performance liquid chromatography (HPLC) of novel chiral stationary phase (CSP) was evaluated. A chiral selector of the CSP investigated in this study (SUMICHIRALTM OA-SHELL P1) is one of helical poly(diphenylacetylene) derivatives which is coated on core-shell silica support. OA-SHELL P1 showed excellent chiral separation ability for a wide range of aromatic chiral alcohols and it was also effective for separation of some chiral carboxylic acids, ketones and lactones. It is considered to be a new option for enantiomeric separation of these chiral compounds. OA-SHELL P1 is used in normal phase mode with a mobile phase of simple composition and one of its features is easy method development. The analysis time is relatively short even with conventional HPLC system since a core-shell support with particle size of 2.6 μm is used.\",\"PeriodicalId\":91226,\"journal\":{\"name\":\"Chromatography (Basel)\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.15583/jpchrom.2019.019\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chromatography (Basel)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15583/jpchrom.2019.019\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chromatography (Basel)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15583/jpchrom.2019.019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Enantiomeric Separation of Chiral Alcohols Using Novel Core-Shell Type Chiral Stationary Phase Coated with Helical Poly(diphenylacetylene) Derivative by High-Performance Liquid Chromatography
Enantiomeric separation ability on high-performance liquid chromatography (HPLC) of novel chiral stationary phase (CSP) was evaluated. A chiral selector of the CSP investigated in this study (SUMICHIRALTM OA-SHELL P1) is one of helical poly(diphenylacetylene) derivatives which is coated on core-shell silica support. OA-SHELL P1 showed excellent chiral separation ability for a wide range of aromatic chiral alcohols and it was also effective for separation of some chiral carboxylic acids, ketones and lactones. It is considered to be a new option for enantiomeric separation of these chiral compounds. OA-SHELL P1 is used in normal phase mode with a mobile phase of simple composition and one of its features is easy method development. The analysis time is relatively short even with conventional HPLC system since a core-shell support with particle size of 2.6 μm is used.
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