柠檬烯,一种在精油中发现的单萜化合物对蓝氏贾第虫的抗寄生作用

Q3 Pharmacology, Toxicology and Pharmaceutics Journal of HerbMed Pharmacology Pub Date : 2023-03-18 DOI:10.34172/jhp.2023.34
Ali Kharazmkia, Javad Ghasemian Yadegari, M. Mohammadian, Rehman Ali, H. Mahmoudvand
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摘要

简介:本研究旨在研究柠檬烯(LMN)对兰第鞭毛虫滋养体和囊体的抗寄生作用。方法:测定LMN(25、50、100 μg/mL)对兰氏梭菌囊体和滋养体的抗贾第虫活性,作用时间为15 ~ 360 min。采用蛋白酶比色法测定LMN对兰氏体的促凋亡作用。结果:贾第虫滋养体对LMN的敏感性高于囊体。LMN在100 μg/mL时效果最佳。LMN分别显著激活了10.2%、25.3%和36.1%的caspase-3活性(P < 0.001)。结论:LMN对兰氏弓形虫具有较强的体外抗贾第鞭毛虫活性,在50和100 μg/mL时活性最高。然而,需要更多的调查来揭示LMN的具体疗效、机制和安全性。
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Antiparasitic effect of limonene, a monoterpene compound found in the essential oils against Giardia lamblia
Introduction: The present work aimed to assess the anti-parasitic effects of limonene (LMN) against Giardia lamblia trophozoites and cysts. Methods: Anti-Giardia activities of LMN (25, 50, and 100 μg/mL) were assessed against G. lamblia cysts and trophozoites for 15-360 minutes. The effects of LMN on the apoptosis stimulation G. lamblia parasites were determined by colorimetric protease assay. Results: Giardia trophozoites were more sensitive to LMN than cysts. The best effect of LMN was seen at 100 μg/mL. LMN markedly triggered caspase-3 activity by 10.2%, 25.3%, and 36.1%, respectively (P < 0.001). Conclusion: We found the potent in vitro anti-giardia activity of LMN against G. lamblia parasites with the maximum activity at 50 and 100 μg/mL. However, additional surveys are necessary to reveal the specific efficacy, mechanisms, and safety of LMN.
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来源期刊
Journal of HerbMed Pharmacology
Journal of HerbMed Pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery
CiteScore
2.50
自引率
0.00%
发文量
49
审稿时长
12 weeks
期刊介绍: Journal of Herbmed Pharmacology (J Herbmed Pharmacol) is the intersection between medicinal plants and pharmacology. This international journal publishes manuscripts in the fields of medicinal plants, pharmacology and therapeutic. This journal aims to reach all relevant national and international medical institutions and persons in electronic version free of charge. J Herbmed Pharmacol has pursued this aim through publishing editorials, original research articles, reviews, mini-reviews, commentaries, letters to the editor, hypothesis, case reports, epidemiology and prevention, news and views. In this journal, particular emphasis is given to research, both experimental and clinical, aimed at protection/prevention of diseases. A further aim of this journal is to emphasize and strengthen the link between herbalists and pharmacologists. In addition, J Herbmed Pharmacol welcomes basic biomedical as well as pharmaceutical scientific research applied to clinical pharmacology. Contributions in any of these formats are invited for editorial consideration following peer review by at least two experts in the field.
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