错误突变在病毒传播能力中的作用

IF 1 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Genes & genetic systems Pub Date : 2022-07-04 DOI:10.1101/2022.06.28.22276997
N. Takahata, Hirotaka Sugawara
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引用次数: 0

摘要

在分析新冠肺炎数据的数学公式中,明确考虑了“错误灾难”所扮演的角色。其想法是将病毒基因座突变的错误突变的数学遗传学形式与流行病的标准模型相结合,后者缺乏对病毒传播的突变效应的明确结合。我们将形式主义应用于严重急性呼吸系统综合征冠状病毒2型的病例。在分析数据的过程中,我们假设了误差突变的“普遍性”。这意味着,描述误差突变的一些基本参数与我们处理的群体(国家或城市)无关。具体来说,我们分析了南非的奥密克戎数据,然后使用南非分析中得出的基本参数的相同值分析了日本的病例。结果表明了我们的普遍性假设的有效性。
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Role of Error Catastrophe in Transmission Ability of Virus
The role played by "error catastrophe" is explicitly taken into account in the mathematical formulation to analyze the COVID-19 data. The idea is to combine the mathematical genetics formalism of the error catastrophe of mutations in the virus gene loci with the standard model of epidemics which lacks the explicit incorporation of the mutation effect on the spreading of the viruses. We apply the formalism to the case of SARS-CoV-2 virus. We assume the "universality" of the error catastrophe in the process of analyzing the data. This means that some basic parameter to describe the error catastrophe is independent of which group (country or city) we deal with. Concretely, we analyze the omicron data of South Africa and then analyze the cases of Japan using the same value of the basic parameter derived in the South Africa analysis. The result shows the validity of our universality assumption.
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来源期刊
Genes & genetic systems
Genes & genetic systems 生物-生化与分子生物学
CiteScore
1.50
自引率
0.00%
发文量
22
审稿时长
>12 weeks
期刊介绍: Genes & Genetic Systems , formerly the Japanese Journal of Genetics , is published bimonthly by the Genetics Society of Japan.
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