底虫胞膜体外抗癌和盐水对虾细胞毒活性的比较。

Q4 Economics, Econometrics and Finance Journal of Medicinal Plants for Economic Development Pub Date : 2020-06-25 DOI:10.4102/jomped.v4i1.73
P. Osamudiamen, O. Aiyelaagbe, Shagun Vaid, P. Sangwan, Abiodun Busuyi Ogbesejana, Ajit K. Saxen
{"title":"底虫胞膜体外抗癌和盐水对虾细胞毒活性的比较。","authors":"P. Osamudiamen, O. Aiyelaagbe, Shagun Vaid, P. Sangwan, Abiodun Busuyi Ogbesejana, Ajit K. Saxen","doi":"10.4102/jomped.v4i1.73","DOIUrl":null,"url":null,"abstract":"Background: Cancer is one of the leading causes of global mortality and recently, it has been established that there is a link between periodontal disease and various types of cancer. In Nigeria, chewing sticks are used especially in the rural areas to maintain oral hygiene and to prevent periodontal disease. Mezoneuron benthamianum is a plant that is used locally as a chewing stick in the southwest of Nigeria, but there has been no report on its anticancer properties. Aim: This study is aimed at determining the anticancer activity using sulforhodamine B (SRB) assay and brine shrimp cytotoxic activity of the extracts of M. benthamianum . Setting: The roots of M. benthamianum were obtained from Ibadan, Oyo State, Nigeria, and were identified and authenticated at the University of Ibadan Herbarium. Methods: The plant sample was subsequently dried, pulverised and extracted with hexane, dichloromethane, ethyl acetate and methanol to give the different extracts which were tested against four cell lines (Lung A549, Lung NCI-H322, Breast T47D and Prostate PC-3) using the SRB assay and were also evaluated against brine shrimp nauplii . Results: The results of the study showed that the different extracts of M. benthamianum had selective and consistent cytotoxic activity against the Lung (A549), Lung (NCI-H322) and Breast (T47D) cell lines, having a percentage growth inhibition ranging from 36% to 63%. The hexane and dichloromethane extracts also gave LC 50 values of 99.96 and 29.29 against brine shrimp cytotoxic activity. Conclusion: These results justify the use of M. benthamianum in folkloric medicine.","PeriodicalId":16345,"journal":{"name":"Journal of Medicinal Plants for Economic Development","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4102/jomped.v4i1.73","citationCount":"4","resultStr":"{\"title\":\"Comparative in-vitro anticancer and brine shrimp cytotoxic activities of Mezoneuron benthamianum Baill.\",\"authors\":\"P. Osamudiamen, O. Aiyelaagbe, Shagun Vaid, P. Sangwan, Abiodun Busuyi Ogbesejana, Ajit K. Saxen\",\"doi\":\"10.4102/jomped.v4i1.73\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Cancer is one of the leading causes of global mortality and recently, it has been established that there is a link between periodontal disease and various types of cancer. In Nigeria, chewing sticks are used especially in the rural areas to maintain oral hygiene and to prevent periodontal disease. Mezoneuron benthamianum is a plant that is used locally as a chewing stick in the southwest of Nigeria, but there has been no report on its anticancer properties. Aim: This study is aimed at determining the anticancer activity using sulforhodamine B (SRB) assay and brine shrimp cytotoxic activity of the extracts of M. benthamianum . Setting: The roots of M. benthamianum were obtained from Ibadan, Oyo State, Nigeria, and were identified and authenticated at the University of Ibadan Herbarium. Methods: The plant sample was subsequently dried, pulverised and extracted with hexane, dichloromethane, ethyl acetate and methanol to give the different extracts which were tested against four cell lines (Lung A549, Lung NCI-H322, Breast T47D and Prostate PC-3) using the SRB assay and were also evaluated against brine shrimp nauplii . Results: The results of the study showed that the different extracts of M. benthamianum had selective and consistent cytotoxic activity against the Lung (A549), Lung (NCI-H322) and Breast (T47D) cell lines, having a percentage growth inhibition ranging from 36% to 63%. The hexane and dichloromethane extracts also gave LC 50 values of 99.96 and 29.29 against brine shrimp cytotoxic activity. Conclusion: These results justify the use of M. benthamianum in folkloric medicine.\",\"PeriodicalId\":16345,\"journal\":{\"name\":\"Journal of Medicinal Plants for Economic Development\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4102/jomped.v4i1.73\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Medicinal Plants for Economic Development\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4102/jomped.v4i1.73\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Economics, Econometrics and Finance\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medicinal Plants for Economic Development","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4102/jomped.v4i1.73","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Economics, Econometrics and Finance","Score":null,"Total":0}
引用次数: 4

摘要

背景:癌症是全球死亡的主要原因之一,最近人们已经确定牙周病与各种类型的癌症之间存在联系。在尼日利亚,尤其是在农村地区,人们使用咀嚼棒来保持口腔卫生和预防牙周病。Mezoneuron benthamianum是一种在尼日利亚西南部被当地用作咀嚼棒的植物,但尚未有关于其抗癌特性的报道。目的:采用磺基罗丹明B(SRB)法测定本氏藻提取物的抗癌活性和卤虾细胞毒活性。背景:本氏M.benthamianum的根来自尼日利亚奥约州的伊巴丹,并在伊巴丹大学植物标本馆进行了鉴定和鉴定。方法:随后将植物样品干燥、粉碎并用己烷、二氯甲烷、乙酸乙酯和甲醇提取,得到不同的提取物,用SRB法对四种细胞系(Lung A549、Lung NCI-H322、Breast T47D和前列腺PC-3)进行测试,并对卤虾无节幼体进行评估。结果:本氏M.benthamianum的不同提取物对肺(A549)、肺(NCI-H322)和乳腺(T47D)细胞系具有选择性和一致的细胞毒性活性,生长抑制率在36%至63%之间。己烷和二氯甲烷提取物对盐水虾的细胞毒性活性也给出了99.96和29.29的LC50值。结论:这些结果证明了本氏菌在民间医学中的应用是合理的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Comparative in-vitro anticancer and brine shrimp cytotoxic activities of Mezoneuron benthamianum Baill.
Background: Cancer is one of the leading causes of global mortality and recently, it has been established that there is a link between periodontal disease and various types of cancer. In Nigeria, chewing sticks are used especially in the rural areas to maintain oral hygiene and to prevent periodontal disease. Mezoneuron benthamianum is a plant that is used locally as a chewing stick in the southwest of Nigeria, but there has been no report on its anticancer properties. Aim: This study is aimed at determining the anticancer activity using sulforhodamine B (SRB) assay and brine shrimp cytotoxic activity of the extracts of M. benthamianum . Setting: The roots of M. benthamianum were obtained from Ibadan, Oyo State, Nigeria, and were identified and authenticated at the University of Ibadan Herbarium. Methods: The plant sample was subsequently dried, pulverised and extracted with hexane, dichloromethane, ethyl acetate and methanol to give the different extracts which were tested against four cell lines (Lung A549, Lung NCI-H322, Breast T47D and Prostate PC-3) using the SRB assay and were also evaluated against brine shrimp nauplii . Results: The results of the study showed that the different extracts of M. benthamianum had selective and consistent cytotoxic activity against the Lung (A549), Lung (NCI-H322) and Breast (T47D) cell lines, having a percentage growth inhibition ranging from 36% to 63%. The hexane and dichloromethane extracts also gave LC 50 values of 99.96 and 29.29 against brine shrimp cytotoxic activity. Conclusion: These results justify the use of M. benthamianum in folkloric medicine.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Medicinal Plants for Economic Development
Journal of Medicinal Plants for Economic Development Economics, Econometrics and Finance-Economics and Econometrics
CiteScore
0.90
自引率
0.00%
发文量
14
审稿时长
32 weeks
期刊最新文献
Bioactivity of plants used traditionally in the treatment and management of men’s sexual health Ethnobotanical survey and anti-candidal activity of plant species used for oral candidiasis Antifungal and antioxidant properties of medicinal plants used against fungal infections Glucose transporter 4 translocation and glucose uptake by selected traditional medicinal preparations Glucose transporter 4 translocation and glucose uptake by selected traditional medicinal preparations
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1