氧化棕榈油损害雌性大鼠的生殖功能和结构

IF 0.5 Q4 REPRODUCTIVE BIOLOGY Asian Pacific Journal of Reproduction Pub Date : 2023-07-01 DOI:10.4103/2305-0500.380985
Wankeu-Nya Modeste, Inès Kengne, Benjamin Ateba, Fort Bend, Ornela Djeumeni, Dominique Hatho, E. Ngadjui, P. Moundipa, D. Massoma, A. Dongmo, Watcho Pierre
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引用次数: 0

摘要

目的:评价3种氧化棕榈油日粮(OPD)对雌性大鼠生殖功能的影响。方法:44只雌性Wistar大鼠连续5个规律的发情周期,随机分为4组。分别饲喂标准日粮、70%标准日粮+30%氧化棕榈油日粮(OPD1)、OPD1+5 g水煮蛋黄蛋(OPD2)和OPD1+10%蔗糖(OPD3) 125 d。在摄食期间,进行形态计量、发情周期、性行为、妊娠、生化及组织形态计量等指标的测定。结果:所有opd均显著增加了小鼠的腹围、体重指数和Lee指数,并伴有发情周期的不规则和延长。他们的食欲和消费行为、定量妊娠指数、生育率、着床部位和指数、血清黄体酮和高密度脂蛋白水平显著降低,着床前损失、抗着床活性、血清雌二醇、甘油三酯、总脂蛋白和低密度脂蛋白-胆固醇水平升高,脑和卵巢氧化状态受损。组织形态学检查显示,与标准饮食组相比,OPD组卵巢中闭锁和初级卵泡数量增加,第二、第三、Degraaf、总卵泡和黄体卵泡数量减少,并伴有下丘脑腹侧脑室周围神经元的神经变性。结论:3种opd诱导肥胖,损害女性生殖功能,以OPD2和OPD3最为明显。这些发现有助于更好地了解棕榈油漂白对雌性大鼠生殖功能的不利影响,这可能对肥胖相关性功能障碍女性的管理有用。
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Oxidized palm oil impairs reproductive functions and architectures in female rats
Objective: To evaluate the effects of three oxidized palm oil diets (OPD) on female rat reproductive function. Methods: Forty-four female Wistar rats presenting five consecutive and regular estrous cycles were divided into 4 groups. The rats were fed with: a standard diet, 70% of standard diet+30% oxidized palm oil diet (OPD1), OPD1+5 g of boiled yolk egg (OPD2) and OPD1+10% sucrose (OPD3) for 125 days, respectively. During the feeding period, morphometric, estrous cycle, sexual behavior, gestation, biochemical and histomorphometric parameters were evaluated. Results: All OPDs significantly increased abdominal circumference, body mass index and Lee index coupled to an irregularity and lengthening of the estrous cycle. They significantly decreased appetite and consumption behaviours, quantic pregnancy index, fertility rate, implantation sites and index, serum progesterone and high-density lipoprotein levels, increased pre-implantation losses, anti-implantation activities, serum estradiol, triglycerides, total and low-density lipoprotein-cholesterol levels, and impaired brain and ovaries oxidative status. Histomorphometric examinations revealed increases in the number of atresic and primary follicles and decreases in secondary, tertiary, Degraaf, total and corpus luteum follicles in ovaries coupled to a neurodegeneration of hypothalamic anteroventral periventricular neurons in the OPD groups compared to the standard diet group. Conclusions: The three OPDs induce obesity and impair the female reproductive function, especially OPD2 and OPD3. These findings contribute to a better understanding of the adverse effects of palm oil bleaching on the reproductive function in female rats, which could be useful in the management of women with obesity-related sexual dysfunction.
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来源期刊
Asian Pacific Journal of Reproduction
Asian Pacific Journal of Reproduction Veterinary-Veterinary (all)
CiteScore
1.70
自引率
0.00%
发文量
588
审稿时长
9 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of Gynecology and Obstetrics. Articles with clinical interest and implications will be given preference.
期刊最新文献
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