金华清肝颗粒UHPLC-Q-提取-Orbitrap-MS分析：45种潜在抗Covid-19成分的推定鉴定、保密添加和药典质量标志物推荐

IF 2.6 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Journal of Food and Drug Analysis Pub Date : 2023-08-31 DOI:10.38212/2224-6614.3466

Jingyuan Zeng, Xican Li, Rongxin Cai, Chunhou Li, Shaoman Chen

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引用次数: 1

摘要

该研究将UHPLC-Q-Orbitrap-MS分析与真实标准相结合，为异构体识别和推定鉴定创造了一种新的策略。通过该策略，发现抗新冠肺炎金花清感颗粒含有28种异构体和45种潜在的抗新冠肺炎成分。三种成分（丹参素、隐丹参素和丹参酮IIA）的检测表明，丹参是一种独特的添加剂。基于此，推荐6种成分作为候选质量标志物，包括绿原酸、acteoside、培蜜辛、黄芩苷、甘草皂苷H2和丹参酮IIA。显然，这项研究不仅可以帮助公众真正了解该颗粒的配方和化学性质，而且有助于今后药典的收集。

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Jinhua Qinggan Granule UHPLC-Q-extractive-Orbitrap-MS assay: Putative identification of 45 potential anti-Covid-19 constituents, confidential addition, and pharmacopoeia quality-markers recommendation

The study combined UHPLC-Q-Orbitrap-MS analysis with authentic standards, to create a novel strategy for isomers recognition and putative identi ﬁ cation. Through the strategy, anti -Covid-19 Jinhua Qinggan Granule was found to comprise 28 isomers and 45 potential anti -Covid-19 constituents. The detection of three constituents (Danshensu, cryptotanshin, and tanshinone IIA) suggests Danshen as con ﬁ dential additive. Based on this, 6 constituents are recommended as quality-marker candidates, including chlorogenic acid, acteoside, peimisine, baicalein, licoricesaponin H2, and tanshinone IIA. Obviously, the study can not only help the public to really understand the Granule ' s formula and chemistry, but also facilitate its Pharmacopoeia collection in future.

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来源期刊

Journal of Food and Drug Analysis 医学-食品科技

CiteScore

6.30

自引率

2.80%

发文量

审稿时长

3.8 months

期刊介绍： The journal aims to provide an international platform for scientists, researchers and academicians to promote, share and discuss new findings, current issues, and developments in the different areas of food and drug analysis. The scope of the Journal includes analytical methodologies and biological activities in relation to food, drugs, cosmetics and traditional Chinese medicine, as well as related disciplines of topical interest to public health professionals.