Evaluation of the Effectiveness of Polyphenols from Grape and Apple Combined with Saffron on Erectile Function: An Observational Study

Thirty-five to fifty-two percent of men are affected by a decline in sex function beyond the age of 40, particularly by a decrease in erectile function resulting from an alteration of microcirculation linked to age and vascular inflammation, but also oxidative stress [1-3]. In the absence of an abnormality inhibiting vascular flow at the level of arterial trunks, decline in erectile function is in fact strongly linked to a lack of bioavailability of nitrous oxide (NO) which by its vasodilatory activity improves the filling of corpora cavernosa with blood [4]. This explains that for many men, the main problem they face is not the frequency of their erections, but their quality and specifically their hardness for which NO plays a major role.